Clinical benefit of a short term dietary oatmeal intervention in patients with type 2 diabetes and severe insulin resistance: a pilot study.

Clinical benefit of a short term dietary oatmeal intervention in patients with type 2 diabetes and severe insulin resistance: a pilot study. Research Abstract Details 

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Clinical benefit of a short term dietary oatmeal intervention in patients with type 2 diabetes and severe insulin resistance: a pilot study. Abstract Text:

A Lammert,J Kratzsch,J Selhorst,P M Humpert,A Bierhaus,R Birck,K Kusterer,H-P Hammes,A Lammert,J Kratzsch,J Selhorst,P M Humpert,A Bierhaus,R Birck,K Kusterer,H-P Hammes,

AIMS/HYPOTHESIS: To evaluate the potential effectiveness of 'carbohydrate days' as a dietary intervention to overcome insulin resistance in type 2 diabetes. MATERIALS AND METHODS: Patients (n=14) with uncontrolled type 2 diabetes and insulin resistance as defined by a dosage of more than 1 IU/day (*)kg BW were consecutively enrolled in this prospective study. Primary outcomes were daily insulin requirement and mean blood glucose levels which were evaluated before, after, and 4 weeks after the intervention. RESULTS: All patients had a metabolic syndrome, 75% had microvascular and 57.1% macrovascular complications. Hospital setting and diabetes adapted diet alone led to improved glycemic control with a mean blood glucose 158+/-47 mg/dl. Intervention with two days of oatmeal diet further decreased mean blood glucose to 118+/-37 mg/dl (p<0.05). This was associated with a significant reduction of insulin dosage by 42.5% (before: 145+/-68.9 U/d, after 83+/-34.2 U/d, p<0.001) as well as a significant reduction (-26.4%, p<0.01) of serum leptin levels.After the four weeks outpatient period, insulin dosage remained significantly decreased (83+/-20.2 U/kg (*)d, p<0.01). Glycemic control was comparable (mean blood glucose141+/-20.78 mg/dl) to glucose levels within the hospital setting. Adiponectin levels increased significantly by 53.8% (p<0.05). CONCLUSIONS: In this uncontrolled pilot study, hospital admission and diabetes adapted diet followed by oatmeal intervention achieved a approximately 40% reduction of insulin dosage required to achieve controlled glucose levels. This effect was conserved after a 4 week outpatient phase with normal diet.

Clinical benefit of a short term dietary oatmeal intervention in patients with type 2 diabetes and severe insulin resistance: a pilot study. Publishing Authors By Initials

A Lammert,J Kratzsch,J Selhorst,PM Humpert,A Bierhaus,R Birck,K Kusterer,HP Hammes,A Lammert,J Kratzsch,J Selhorst,PM Humpert,A Bierhaus,R Birck,K Kusterer,HP Hammes,

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Clinical benefit of a short term dietary oatmeal intervention in patients with type 2 diabetes and severe insulin resistance: a pilot study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental and clinical endocrinology & diabetes

VOLUME: 116

Page Numbers: 132-4

Journal Abbreviation: Exp. Clin. Endocrinol. Diabete

ISSN: 0947-7349

DAY: 20

MONTH: 12

YEAR: 2007

Clinical benefit of a short term dietary oatmeal intervention in patients with type 2 diabetes and severe insulin resistance: a pilot study. Information

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LANGUAGE: eng

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AFFILIATION: 1V. Medizinische Klinik, University Hospital Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany.

Country: Germany

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MEDLINETA: Exp Clin Endocrinol Diabetes

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