Clinical applications of PET in brain tumors.

Clinical applications of PET in brain tumors. Research Abstract Details 

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Clinical applications of PET in brain tumors. Abstract Text:

Wei Chen,

Malignant gliomas and metastatic tumors are the most common brain tumors. Neuroimaging plays a significant role clinically. In low-grade tumors, neuroimaging is needed to evaluate recurrent disease and to monitor anaplastic transformation into high-grade tumors. In high-grade and metastatic tumors, the imaging challenge is to distinguish between recurrent tumor and treatment-induced changes such as radiation necrosis. The current clinical gold standard, MRI, provides superior structural detail but poor specificity in identifying viable tumors in brain treated with surgery, radiation, or chemotherapy. (18)F-FDG PET identifies anaplastic transformation and has prognostic value. The sensitivity and specificity of (18)F-FDG in evaluating recurrent tumor and treatment-induced changes can be improved significantly by co-registration with MRI and potentially by delayed imaging 3-8 h after injection. Amino acid PET tracers are more sensitive than (18)F-FDG in imaging recurrent tumors and in particular recurrent low-grade tumors. They are also promising in differentiating between recurrent tumors and treatment-induced changes.

Clinical applications of PET in brain tumors. Publishing Authors By Initials

W Chen,

For similar chemical actions and uses: specialty uses of chemicals: laboratory chemicals: indicators and reagents: radiopharmaceuticals research abstracts see: chemical actions and uses: specialty uses of chemicals: laboratory chemicals: indicators and reagents: radiopharmaceuticals research

PUBMED ID PMID:

MEDLINE DATE:

Clinical applications of PET in brain tumors. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of nuclear medicine : official publication

VOLUME: 48

Page Numbers: 1468-81

Journal Abbreviation: J. Nucl. Med.

ISSN: 0161-5505

DAY: 17

MONTH: 08

YEAR: 2007

Clinical applications of PET in brain tumors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 217410

Clinical applications of PET in brain tumors. Keywords Mesh Terms:

KEYWORDS: Radiopharmaceuticals

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: Clinical applications of PET in brain tumors. Information

Substance Name: Fluorodeoxyglucose F18

Registry Number: 63503-12-8

Grant and Affiliation Information for Clinical applications of PET in brain tumors.

AFFILIATION: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California-Los Angeles, CA, USA. weichen@mednet.ucla.edu

Country: United States

AGENCY: United States NCI

GRANT: P50 CA 086306

ACRONYM: CA

MEDLINETA: J Nucl Med

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