Clinical and immunohistochemical study of immunoglobulin A nephropathy (IgAN) before and after tonsillectomy.

Clinical and immunohistochemical study of immunoglobulin A nephropathy (IgAN) before and after tonsillectomy. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Clinical and immunohistochemical study of immunoglobulin A nephropathy (IgAN) before and after tonsillectomy. Abstract Text:

Katsushige Abe,Masanobu Miyazaki,Kei Shioshita,Takashi Harada,Takehiko Koji,Shigeru Kohno,

Tonsillectomy often improves clinical features in immunoglobulin A nephropathy (IgAN), however, the mechanisms mediating clinical modifications are unclear. In the present study, we examined the immunohistological alterations in biopsy specimens obtained from IgAN patients before and after tonsillectomy. We investigated eight IgAN patients who underwent repeated renal biopsy in the present study. Immunohistochemistry for alpha-smooth muscle actin (alpha-SMA), CD68 and proliferating cell nuclear antigen (PCNA) were performed and histological findings were compared before and after tonsillectomy. None of the patients were treated with steroids or immunosuppressive drugs before second renal biopsy. The expression of alpha-SMA and the number of CD68 positive cells were significantly decreased in IgAN patients with improvement of proteinuria and hematuria after tonsillectomy. The degree of mesangial cell proliferation, expansion of mesangial area and the number of PCNA positive cells were not changed after tonsillectomy. These results suggest that the reduced number of activated mesangial cells and macrophages may be involved in the improvement of hematuria after tonsillectomy. They also suggest that tonsillectomy may improve proteinuria and hematuria in some patients with IgAN through reduction of mesangial cell activation and macrophage infiltration.

Clinical and immunohistochemical study of immunoglobulin A nephropathy (IgAN) before and after tonsillectomy. Publishing Authors By Initials

K Abe,M Miyazaki,K Shioshita,T Harada,T Koji,S Kohno,

For similar surgical procedures, operative: otorhinolaryngologic surgical procedures: tonsillectomy research abstracts see: surgical procedures, operative: otorhinolaryngologic surgical procedures: tonsillectomy research

PUBMED ID PMID:

MEDLINE DATE:

Clinical and immunohistochemical study of immunoglobulin A nephropathy (IgAN) before and after tonsillectomy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta oto-laryngologica. Supplementum

VOLUME:

Page Numbers: 20-4

Journal Abbreviation:

ISSN: 0365-5237

DAY: 13

MONTH: Dec

YEAR: 2004

Clinical and immunohistochemical study of immunoglobulin A nephropathy (IgAN) before and after tonsillectomy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370355

Clinical and immunohistochemical study of immunoglobulin A nephropathy (IgAN) before and after tonsillectomy. Keywords Mesh Terms:

KEYWORDS: Tonsillectomy

MESH TERMS: analysis

Chemical & Substance for Abstract: Clinical and immunohistochemical study of immunoglobulin A nephropathy (IgAN) before and after tonsillectomy. Information

Substance Name: Proliferating Cell Nuclear Antigen

Registry Number: 0

Grant and Affiliation Information for Clinical and immunohistochemical study of immunoglobulin A nephropathy (IgAN) before and after tonsillectomy.

AFFILIATION: Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan. rukonyan@ga2.so-net.ne.jp

Country: Norway

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Acta Otolaryngol Suppl

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Clinical and immunohistochemical study of immunoglobulin A nephropathy IgAN before and after tonsillectomy Related Publications

• Acute hepatitis E of a man who consumed wild boar meat prior to the onset of illness in Nagasaki, Japan.
• Association of uncoupling protein-2 expression with increased reactive oxygen species in residual myocardium of the enlarged left ventricle after myocardial infarction.
• Bone morphogenetic protein-2 promotes survival and differentiation of striatal GABAergic neurons in the absence of glial cell proliferation.
• Cardiac function as assessed by echocardiography in the oldest old >/= 90 years of age.
• Circulating visfatin level is correlated with inflammation, but not with insulin resistance.
• Comparison of the grade evaluated by "Liver damage" of Liver Cancer Study Group of Japan and Child-Pugh classification in patients with hepatocellular carcinoma.
• Crystallization and preliminary crystallographic analysis of an octaketide-producing plant type III polyketide synthase.
• Detection of new antigenic proteins in Japanese cedar pollen.
• Differential expression of the glycosylated forms of MUC1 during lung development.
• Effects of acetaldehyde on human airway constriction and inflammation.
• Expression of aldosterone synthase gene in IgA nephropathy (IgAN).
• Granulocyte colony-stimulating factor facilitates the angiogenesis induced by ultrasonic microbubble destruction.
• How transmembrane proteins sense endoplasmic reticulum stress.
• In vitro and in vivo activities of novel fluoroquinolones alone and in combination with clarithromycin against clinically isolated Mycobacterium avium complex strains in Japan.
• Intracellular balance of oxidative stress and cytoprotective molecules in damaged interlobular bile ducts in autoimmune hepatitis and primary biliary cirrhosis: In situ detection of 8-hydroxydeoxyguanosine and glutathione-S-transferase-pi.
• Latent cardiac dysfunction as assessed by echocardiography in bed-bound patients following cerebrovascular accidents.
• Low-dose oral methotrexate for the management of childhood Cogan's syndrome: a case report.
• Phase I study of irinotecan and gemcitabine in previously untreated patients with advanced non-small cell lung cancer.
• Recent advances in understanding the unfolded protein response.
• Serum marker KL-6/MUC1 for the diagnosis and management of interstitial pneumonitis.
• Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstruction.
• Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in PC12 cells by bone morphogenetic protein-2.
• Structural insight into chain-length control and product specificity of pentaketide chromone synthase from Aloe arborescens.
• Suppression of renal tubulointerstitial fibrosis by small interfering RNA targeting heat shock protein 47.
• Telephone counseling of athletes abusing anabolic-androgenic steroids.
• Transgenic mice expressing a fully nontoxic diphtheria toxin mutant, not CRM197 mutant, acquire immune tolerance against diphtheria toxin.
• Wireless Vital Sign Monitoring using Ultra Wideband-Based Personal Area Networks.
• [A case of idiopathic chylothorax successfully treated with surgical ligation of thoracic ducts]
• [A case of mycoplasmal pneumonia with bronchiolitis treated with steroids]
• [Nontuberculous mycobacterial infections involving solitary pulmonary nodules]