Clinical and economic impact of multidrug resistance in nosocomial Acinetobacter baumannii bacteremia.

Clinical and economic impact of multidrug resistance in nosocomial Acinetobacter baumannii bacteremia. Research Abstract Details 

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Clinical and economic impact of multidrug resistance in nosocomial Acinetobacter baumannii bacteremia. Abstract Text:

Nan-Yao Lee,Hsin-Chun Lee,Nai-Ying Ko,Chia-Ming Chang,Hsin-I Shih,Chi-Jung Wu,Wen-Chien Ko,Nan-Yao Lee,Hsin-Chun Lee,Nai-Ying Ko,Chia-Ming Chang,Hsin-I Shih,Chi-Jung Wu,Wen-Chien Ko,

OBJECTIVE: To investigate the impact of antimicrobial resistance on clinical and economic outcomes among hospitalized patients with multidrug-resistant (MDR) Acinetobacter baumannii bacteremia. DESIGN: A retrospective, matched-cohort study. SETTING: A tertiary care university teaching hospital. METHODS: A matched case-control (1 : 1) study was conducted to compare the differences in clinical and economic outcomes of patients with MDR A. baumannii bacteremia and patients with non-MDR A. baumannii bacteremia. Case patients were matched to control patients on the basis of sex, age, severity of underlying and acute illness, and length of hospital stay before onset of bacteremia. RESULTS: Forty-six (95.8%) of 48 cases with MDR A. baumannii bacteremia were eligible for the study and matched with appropriate controls. The sepsis-related mortality rate was 34.8% among cases and 13.0% among controls, for an attributable mortality rate of 21.8% (adjusted odds ratio, 4.1 [95% confidence interval, 1.1-15.7]; P=.036). After the onset of bacteremia, cases and controls had a significantly different length of hospital stay (54.2 vs 34.1 days; P=.006), hospitalization cost (US$9,349 vs US$4,865; P=.001), and antibiotic therapy cost (US$2,257 vs US$1,610; P=.014). Thus, bacteremia due to MDR A. baumannii resulted in 13.4 days of additional hospitalization and US$3,758 of additional costs, compared with bacteremia due to non-MDR A. baumannii. CONCLUSIONS: Patients with MDR A. baumannii bacteremia had a higher mortality rate and incurred greater medical costs than patients with non-MDR A. baumannii bacteremia.

Clinical and economic impact of multidrug resistance in nosocomial Acinetobacter baumannii bacteremia. Publishing Authors By Initials

NY Lee,HC Lee,NY Ko,CM Chang,HI Shih,CJ Wu,WC Ko,NY Lee,HC Lee,NY Ko,CM Chang,HI Shih,CJ Wu,WC Ko,

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Clinical and economic impact of multidrug resistance in nosocomial Acinetobacter baumannii bacteremia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Infection control and hospital epidemiology : the

VOLUME: 28

Page Numbers: 713-9

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ISSN: 0899-823X

DAY: 14

MONTH: 05

YEAR: 2007

Clinical and economic impact of multidrug resistance in nosocomial Acinetobacter baumannii bacteremia. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Clinical and economic impact of multidrug resistance in nosocomial Acinetobacter baumannii bacteremia.

AFFILIATION: Department of Internal Medicine, Division of Infectious Diseases, National Cheng Kung University Hospital, Tainan, Taiwan.

Country: United States

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MEDLINETA: Infect Control Hosp Epidemiol

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