Clearance of amyloid-beta by circulating lipoprotein receptors.

Clearance of amyloid-beta by circulating lipoprotein receptors. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Clearance of amyloid-beta by circulating lipoprotein receptors. Abstract Text:

Abhay Sagare,Rashid Deane,Robert D Bell,Bradley Johnson,Katie Hamm,Ronan Pendu,Andrew Marky,Peter J Lenting,Zhenhua Wu,Troy Zarcone,Alison Goate,Kevin Mayo,David Perlmutter,Mireia Coma,Zhihui Zhong,Berislav V Zlokovic,

Low-density lipoprotein receptor-related protein-1 (LRP) on brain capillaries clears amyloid beta-peptide (Abeta) from brain. Here, we show that soluble circulating LRP (sLRP) provides key endogenous peripheral 'sink' activity for Abeta in humans. Recombinant LRP cluster IV (LRP-IV) bound Abeta in plasma in mice and Alzheimer's disease-affected humans with compromised sLRP-mediated Abeta binding, and reduced Abeta-related pathology and dysfunction in a mouse model of Alzheimer disease, suggesting that LRP-IV can effectively replace native sLRP and clear Abeta.

Clearance of amyloid-beta by circulating lipoprotein receptors. Publishing Authors By Initials

A Sagare,R Deane,RD Bell,B Johnson,K Hamm,R Pendu,A Marky,PJ Lenting,Z Wu,T Zarcone,A Goate,K Mayo,D Perlmutter,M Coma,Z Zhong,BV Zlokovic,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Clearance of amyloid-beta by circulating lipoprotein receptors. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Nature medicine

VOLUME: 13

Page Numbers: 1029-31

Journal Abbreviation: Nat. Med.

ISSN: 1078-8956

DAY: 12

MONTH: 08

YEAR: 2007

Clearance of amyloid-beta by circulating lipoprotein receptors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9502015

Clearance of amyloid-beta by circulating lipoprotein receptors. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Clearance of amyloid-beta by circulating lipoprotein receptors. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Clearance of amyloid-beta by circulating lipoprotein receptors.

AFFILIATION: Frank P. Smith Laboratory for Neuroscience and Neurosurgical Research, Department of Neurosurgery, University of Rochester Medical School, Rochester, New York 14642, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R37 NS34467

ACRONYM: NS

MEDLINETA: Nat Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Clearance of amyloid-beta by circulating lipoprotein receptors Related Publications

• ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration.
• Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage.
• Clearance of amyloid-beta by circulating lipoprotein receptors.
• Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice.
• New therapeutic targets in the neurovascular pathway in Alzheimer's disease.
• Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype.
• The blood-brain barrier in health and chronic neurodegenerative disorders.
• The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease.
• Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system.