Cleaning validation 2: development and validation of an ion chromatographic method for the detection of traces of CIP-100 detergent.

Cleaning validation 2: development and validation of an ion chromatographic method for the detection of traces of CIP-100 detergent. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Cleaning validation 2: development and validation of an ion chromatographic method for the detection of traces of CIP-100 detergent. Abstract Text:

Wilfredo Resto,Darimar ,Rosamil Rey, , Zayas,

A cleaning validation method, ion chromatographic method with conductivity detection was developed and validated for the determination of traces of a clean-in-place (CIP) detergent. It was shown to be linear with a squared correlation coefficient (r(2)) of 0.9999 and average recoveries of 71.4% (area response factor) from stainless steel surfaces and 101% from cotton. The repeatability was found to be 2.17% and an intermediate precision of 1.88% across the range. The method was also shown to be sensitive with a detection limit (DL) of 0.13 ppm and a quantitation limit (QL) of 0.39 ppm for EDTA, which translates to less than 1 microL of CIP diluted in 100mL of diluent in both cases. The EDTA signal was well resolved from typical ions encountered in water samples or any other interference presented from swabs and surfaces. The method could be applied to cleaning validation samples. The validated method could be included as a suitable one for rapid and reliable cleaning validation program.

Cleaning validation 2: development and validation of an ion chromatographic method for the detection of traces of CIP-100 detergent. Publishing Authors By Initials

W Resto,D ,R Rey,H ,J Zayas,

For similar investigative techniques: technology, pharmaceutical research abstracts see: investigative techniques: technology, pharmaceutical research

PUBMED ID PMID:

MEDLINE DATE:

Cleaning validation 2: development and validation of an ion chromatographic method for the detection of traces of CIP-100 detergent. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of pharmaceutical and biomedical analysis

VOLUME: 44

Page Numbers: 265-9

Journal Abbreviation:

ISSN: 0731-7085

DAY: 30

MONTH: 01

YEAR: 2007

Cleaning validation 2: development and validation of an ion chromatographic method for the detection of traces of CIP-100 detergent. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8309336

Cleaning validation 2: development and validation of an ion chromatographic method for the detection of traces of CIP-100 detergent. Keywords Mesh Terms:

KEYWORDS: Technology, Pharmaceutical

MESH TERMS: chemistry

Chemical & Substance for Abstract: Cleaning validation 2: development and validation of an ion chromatographic method for the detection of traces of CIP-100 detergent. Information

Substance Name: Edetic Acid

Registry Number: 60-00-4

Grant and Affiliation Information for Cleaning validation 2: development and validation of an ion chromatographic method for the detection of traces of CIP-100 detergent.

AFFILIATION: Department of Chemistry, University of Puerto Rico-Cayey, Antonio R. Barceló Ave. Cayey, PR 00736, USA.

Country: England

AGENCY: United States NIGMS

GRANT: 5R25 GM59429-08

ACRONYM: GM

MEDLINETA: J Pharm Biomed Anal

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Cleaning validation 2: development and validation of an ion chromatographic method for the detection of traces of CIP-100 detergent Related Publications

• "It's like being in a labyrinth:" Hispanic immigrants' perceptions of depression and attitudes toward treatments.
• Cleaning validation 2: development and validation of an ion chromatographic method for the detection of traces of CIP-100 detergent.
• Consistent efficacy and tolerability of almotriptan in the acute treatment of multiple migraine attacks: results of a large, randomized, double-blind, placebo-controlled study.
• Effect of ultrasound treatment on the extraction of insulin.
• Eosinophil cationic protein in feces: reference values in healthy and atopic individuals and patients with digestive diseases.
• Glomerular involvement in adults with sickle cell hemoglobinopathies: Prevalence and clinical correlates of progressive renal failure.
• Latino immigrants' intentions to seek depression care.
• Maternal depression and adolescent behavior problems: an examination of mediation among immigrant Latino mothers and their adolescent children exposed to community violence.
• Mucomodulator therapy in cystic fibrosis: balancing mucus clearability against the spread of airborne pathogens.
• Properties and quality characteristics of crystalline insulin extracted by ultrasound.
• Properties and quality characteristics of rennin extracted by ultrasound.
• Six-month multicomponent intervention improves postnatal depression in low-income settings.