Class A carbapenemases.

Class A carbapenemases. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Class A carbapenemases. Abstract Text:

Jan Walther-Rasmussen,Niels ,Jan Walther-Rasmussen,Niels ,

Carbapenems, such as imipenem and meropenem, are most often used to treat infections caused by enterobacteria that produce extended-spectrum beta-lactamases, and the emergence of enzymes capable of inactivating carbapenems would therefore limit the options for treatment. Carbapenem resistance in Enterobacteriaceae is rare, but class A beta-lactamases with activity against the carbapenems are becoming more prevalent within this bacterial family. The class A carbapenemases can phylogenetically be segregated into six different groups of which four groups are formed by members of the GES, KPC, SME, IMI/NMC-A enzymes, while SHV-38 and SFC-1 each separately constitute a group. The genes encoding the class A carbapenemases are either plasmid-borne or located on the chromosome of the host. The bla(GES) genes reside as gene cassettes on mainly class I integrons, whereas the bla(KPC) genes and a single bla(IMI-2) gene are flanked by transposable elements on plasmids. Class A carbapenemases hydrolyse penicillins, classical cephalosporins, monobactam, and imipenem and meropenem, and the enzymes are divided into four phenotypically different groups, namely group 2br, 2be, 2e and 2f, according to the Bush-Jacoby-Medeiros classification system. Class A carbapenemases are inhibited by clavulanate and tazobactam like other class A beta-lactamases.

Class A carbapenemases. Publishing Authors By Initials

J Walther-Rasmussen,N ,J Walther-Rasmussen,N ,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Class A carbapenemases. Journal Published:

PUBLICATION TYPE: Review

Journal: The Journal of antimicrobial chemotherapy

VOLUME: 60

Page Numbers: 470-82

Journal Abbreviation: J. Antimicrob. Chemother.

ISSN: 0305-7453

DAY: 26

MONTH: 06

YEAR: 2007

Class A carbapenemases. Information

Number of References: 120

LANGUAGE: eng

NlmUniqueID: 7513617

Class A carbapenemases. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Class A carbapenemases. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Class A carbapenemases.

AFFILIATION: Department of Clinical Microbiology, 9301, Rigshospitalet, National University Hospital, Copenhagen, Denmark. jawalras@mail.tele.dk

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Antimicrob Chemother

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Class A carbapenemases Related Publications

• Activated complement in the sputum from patients with cystic fibrosis.
• Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice.
• Changes in serotype caused by cell to cell contact between different Pseudomonas aeruginosa strains from cystic fibrosis patients.
• Class A carbapenemases.
• Crossed immunoelectrophoretic analysis of Flavobacterium meningosepticum and allied Flavobacterium taxa.
• Crossed immunoelectrophoretic analysis of Neisseria meningitidis antigens and of corresponding antibodies in patients with meningococcal disease.
• Effect of Pseudomonas aeruginosa proteases on human leukocyte phagocytosis and bactericidal activity.
• Effect of aerobic and anaerobic atmosphere on the detection of micro-organisms from blood cultures.
• Effect of antimalarial drugs on human neutrophil chemotaxis in vitro.
• Immunoglobulins and albumin in sputum from patients with cystic fibrosis. A study of protein stability and presence of proteases.
• Polyagglutinability due to loss of O-antigenic determinants in Pseudomonas aeruginosa strains isolated from cystic fibrosis patients.
• Precipitating antibodies against Neisseria meningitidis in normal sera and their possible origin.
• Prevention and treatment of infections in cystic fibrosis.
• Pseudomonas aeruginosa diversity in distinct paediatric patient groups.
• Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa.
• [A good reason to be on guard]
• [Blood cultures in general practice. Suspected meningococcal disease and other serious infections with bacteremia]
• [In Process Citation]
• [New recommendations for antibiotic dosing in patients with renal insufficiency and in patients undergoing haemodialysis]