Cisplatin-induced long-term dynorphin A-immunoreactivity in cell somata of rat area postrema neurons.

Cisplatin-induced long-term dynorphin A-immunoreactivity in cell somata of rat area postrema neurons. Research Abstract Details 

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Cisplatin-induced long-term dynorphin A-immunoreactivity in cell somata of rat area postrema neurons. Abstract Text:

Goichi Tsukamoto,Hiroyuki Ichikawa,Motoi Kobashi,Yosuke Yamada,Takeshi Kikuchi,Hiroshi Mese,Akira Sasaki,Goichi Tsukamoto,Hiroyuki Ichikawa,Motoi Kobashi,Yosuke Yamada,Takeshi Kikuchi,Hiroshi Mese,Akira Sasaki,

We evaluated long-term dynorphin A-immunoreactivity in the rat area postrema (AP) after the administration of cisplatin. First, rats were given 1, 5 and 10mg/kg body weight cisplatin (i.p.) and their behavior was monitored for 72h. We observed a delayed increase in pica 24-72h after injection, compared to the 24h before injection. We attributed this to the cisplatin injection. Pica was defined as an increase in the intake of non-nutritional matter such as kaolin. Administration of 1, 5 and 10mg/kg cisplatin led to an increase in kaolin intake on day 1. Administration of 5 and 10mg/kg of cisplatin led to decreased intake of laboratory chow (MF) on days 1-3, but 10mg/kg cisplatin causes an excessive aggravation of their condition. Following this behavioral experiment, we immunohistochemically examined the induction of dynorphin A in the AP at 24, 48 and 72h post-administration of 1 and 5mg/kg cisplatin. Administration of 5mg/kg cisplatin caused dynorphin A to accumulate gradually in the neurosoma of the AP neurons, and the numbers of positive AP neurosomata at 48 and 72h post-administration were higher than following an equal dosage of 0.9% NaCl. These findings suggest that dynorphin A increases in the central nervous system for a long time following administration, and causes certain behavioral and clinical changes, including those related to appetite and nausea.

Cisplatin-induced long-term dynorphin A-immunoreactivity in cell somata of rat area postrema neurons. Publishing Authors By Initials

G Tsukamoto,H Ichikawa,M Kobashi,Y Yamada,T Kikuchi,H Mese,A Sasaki,G Tsukamoto,H Ichikawa,M Kobashi,Y Yamada,T Kikuchi,H Mese,A Sasaki,

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Cisplatin-induced long-term dynorphin A-immunoreactivity in cell somata of rat area postrema neurons. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuroscience letters

VOLUME: 424

Page Numbers: 122-6

Journal Abbreviation: Neurosci. Lett.

ISSN: 0304-3940

DAY: 8

MONTH: 08

YEAR: 2007

Cisplatin-induced long-term dynorphin A-immunoreactivity in cell somata of rat area postrema neurons. Information

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LANGUAGE: eng

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AFFILIATION: Department of Oral and Maxillofacial Surgery, Biopathological Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8525, Japan. gtsuka@md.okayama-u.ac.jp

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MEDLINETA: Neurosci Lett

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