Cisapride in functional dyspepsia: a double-blind, placebo-controlled randomized trial in general practice patients.

Cisapride in functional dyspepsia: a double-blind, placebo-controlled randomized trial in general practice patients. Research Abstract Details 

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Cisapride in functional dyspepsia: a double-blind, placebo-controlled randomized trial in general practice patients. Abstract Text:

S F Wood,S C Penney,K M Cochran,

This trial included patients from general practice with endoscopy-negative chronic dyspepsia and epigastric pain or discomfort. Eleven eligible patients with sufficiently severe dyspeptic symptoms after a 2-week placebo run-in period were entered into a 4-week, parallel group, double-blind randomized comparison of 10 mg cisapride three times daily and matched placebo, and were subsequently evaluable. Symptoms were comparable in the two treatment groups at the start of double-blind treatment. The cisapride group had a significantly greater reduction in the frequency of daytime epigastric pain/discomfort and the frequency and severity of nocturnal pain/discomfort after 2 weeks. After 2 weeks, all six cisapride recipients were free of nocturnal pain, compared with only one of five placebo recipients. After 4 weeks of double-blind therapy, improvements in the placebo group had reduced between-treatment differences, with five of six cisapride recipients and three of five placebo recipients being free of nocturnal pain. Cisapride was well tolerated.

Cisapride in functional dyspepsia: a double-blind, placebo-controlled randomized trial in general practice patients. Publishing Authors By Initials

SF Wood,SC Penney,KM Cochran,

For similar heterocyclic compounds: heterocyclic compounds, 1-ring: piperidines research abstracts see: heterocyclic compounds: heterocyclic compounds, 1-ring: piperidines research

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Cisapride in functional dyspepsia: a double-blind, placebo-controlled randomized trial in general practice patients. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: Scandinavian journal of gastroenterology. Suppleme

VOLUME: 195

Page Numbers: 5-10

Journal Abbreviation: Scand. J. Gastroenterol. Suppl

ISSN: 0085-5928

DAY: 13

MONTH: 02

YEAR: 1993

Cisapride in functional dyspepsia: a double-blind, placebo-controlled randomized trial in general practice patients. Information

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LANGUAGE: eng

NlmUniqueID: 437034

Cisapride in functional dyspepsia: a double-blind, placebo-controlled randomized trial in general practice patients. Keywords Mesh Terms:

KEYWORDS: Piperidines

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Cisapride in functional dyspepsia: a double-blind, placebo-controlled randomized trial in general practice patients. Information

Substance Name: Cisapride

Registry Number: 81098-60-4

Grant and Affiliation Information for Cisapride in functional dyspepsia: a double-blind, placebo-controlled randomized trial in general practice patients.

AFFILIATION: University of Glasgow Dept. of General Practice, Woodside Health Centre, Scotland.

Country: NORWAY

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MEDLINETA: Scand J Gastroenterol Suppl

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