Circulating stem cells in extremely preterm neonates.

Circulating stem cells in extremely preterm neonates. Research Abstract Details 

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Circulating stem cells in extremely preterm neonates. Abstract Text:

Matthew J Bizzarro,Vineet Bhandari,Diane S Krause,Brian R Smith,Ian Gross,

AIM: To measure circulating CD34+ cell levels in premature neonates and to correlate the initial CD34+ counts with measures of pulmonary function and neonatal morbidity. METHODS: CD34+ cell counts were measured in the peripheral blood of preterm neonates (gestational ages 24-32 weeks) ventilated for respiratory disease at <48 h of life, and at the start of the 2nd, 3rd and 4th weeks of life. Data pertaining to neonatal demographics and short-term outcomes were collected. Pulmonary function tests were performed to coincide with CD34+ sampling. RESULTS: Thirty preterm neonates with median gestational age of 24 weeks and birth weight of 641 g were analysed. A mean of 99.4 CD34+ cells per microliter was observed in the 1st week of life with a decline to 54.4 cells per microliter by the 4th week. An inverse correlation between initial CD34+ count and gestational age (p=0.01) was observed. No significant correlations were observed with measures of pulmonary function or neonatal morbidities. CONCLUSIONS: Extremely premature neonates have remarkably high levels of CD34+ cells in their peripheral blood at birth. Umbilical cord blood from this population may potentially provide an abundant source of hematopoietic stem and progenitor cells for therapeutic purposes.

Circulating stem cells in extremely preterm neonates. Publishing Authors By Initials

MJ Bizzarro,V Bhandari,DS Krause,BR Smith,I Gross,

For similar diagnosis: diagnostic techniques and procedures: diagnostic techniques, respiratory system: respiratory function tests research abstracts see: diagnosis: diagnostic techniques and procedures: diagnostic techniques, respiratory system: respiratory function tests research

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Circulating stem cells in extremely preterm neonates. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Acta paediatrica (Oslo, Norway : 1992)

VOLUME: 96

Page Numbers: 521-5

Journal Abbreviation: Acta Paediatr.

ISSN: 0803-5253

DAY: 3

MONTH: Apr

YEAR: 2007

Circulating stem cells in extremely preterm neonates. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9205968

Circulating stem cells in extremely preterm neonates. Keywords Mesh Terms:

KEYWORDS: Respiratory Function Tests

MESH TERMS: complications

Chemical & Substance for Abstract: Circulating stem cells in extremely preterm neonates. Information

Substance Name: Antigens, CD34

Registry Number: 0

Grant and Affiliation Information for Circulating stem cells in extremely preterm neonates.

AFFILIATION: Department of Pediatrics, Division of Perinatal Medicine, Yale University School of Medicine, New Haven, CT 06520-8064, USA. matthew.bizzarro@yale.edu

Country: Norway

AGENCY: United States NICHD

GRANT: T32 HD 07094

ACRONYM: HD

MEDLINETA: Acta Paediatr

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