Circulating leucocyte adhesion molecules in chronic venous insufficiency.

Circulating leucocyte adhesion molecules in chronic venous insufficiency. Research Abstract Details 

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Circulating leucocyte adhesion molecules in chronic venous insufficiency. Abstract Text:

G Ciuffetti,R Lombardini,L Pasqualini,G Vaudo,G Lupattelli,

BACKGROUND: Enzyme-linked immunosorbent assay (ELISA) techniques have detected the existence of circulating forms of intercellular adhesion molecule-1 (ICAM-1), vascular endothelial adhesion molecule-1 (VCAM-1) and E-selectin, all of which mediate leucocyte-endothelial adhesion. This study determined whether circulating cell adhesion molecules were increased in patients with chronic venous insufficiency (CVI) which causes venous stasis. PATIENTS AND METHODS: Before and after walking and upon recovery blood samples were drawn from the saphenous vein in 20 CVI patients: 10 with varicose veins (group 1), 10 with deep venous insufficiency (group 2). 10 healthy controls were enrolled. The total leucocyte count and the soluble levels of ICAM-1, VCAM-1 and E-selectin were determined. RESULTS: After walking, the total leucocyte count decreased significantly (p < 0.01) only in group 2 and sICAM-1 and sVCAM-1 increased significantly (p < 0.01). Upon recovery, these significant differences remained in group 2. No significant modification was observed at any stage of the study in group 1 or in the control group. CONCLUSIONS: These results suggest persistently high levels of circulating adhesion molecules may contribute to worsen microvascular perfusion, which leads to the onset of trophic damage in CVI.

Circulating leucocyte adhesion molecules in chronic venous insufficiency. Publishing Authors By Initials

G Ciuffetti,R Lombardini,L Pasqualini,G Vaudo,G Lupattelli,

For similar cardiovascular diseases: vascular diseases: venous insufficiency research abstracts see: cardiovascular diseases: vascular diseases: venous insufficiency research

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Circulating leucocyte adhesion molecules in chronic venous insufficiency. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: VASA. Zeitschrift für Gefässkrankheiten. Journal f

VOLUME: 28

Page Numbers: 156-9

Journal Abbreviation: VASA

ISSN: 0301-1526

DAY: 13

MONTH: Aug

YEAR: 1999

Circulating leucocyte adhesion molecules in chronic venous insufficiency. Information

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LANGUAGE: eng

NlmUniqueID: 317051

Circulating leucocyte adhesion molecules in chronic venous insufficiency. Keywords Mesh Terms:

KEYWORDS: Venous Insufficiency

MESH TERMS: immunology

Chemical & Substance for Abstract: Circulating leucocyte adhesion molecules in chronic venous insufficiency. Information

Substance Name: Intercellular Adhesion Molecule-1

Registry Number: 126547-89-5

Grant and Affiliation Information for Circulating leucocyte adhesion molecules in chronic venous insufficiency.

AFFILIATION: Department of Clinical and Experimental Medicine, University of Perugia, Italy.

Country: SWITZERLAND

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MEDLINETA: Vasa

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