Circulating insulin-like growth factor binding protein-1 and the risk of pancreatic cancer.

Circulating insulin-like growth factor binding protein-1 and the risk of pancreatic cancer. Research Abstract Details 

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Circulating insulin-like growth factor binding protein-1 and the risk of pancreatic cancer. Abstract Text:

Brian M Wolpin,Dominique S Michaud,Edward L Giovannucci,Eva S Schernhammer,Meir J Stampfer,JoAnn E Manson,Barbara B Cochrane,Thomas E Rohan,Jing Ma,Michael N Pollak,Charles S Fuchs,

Insulin-like growth factor (IGF)-I has growth-promoting effects on pancreatic cancer cells, and elevated fasting serum insulin has been linked to pancreatic cancer risk. IGF binding protein-1 (IGFBP-1) is a downstream target of insulin and inhibits IGF-I activity. To investigate whether prediagnostic plasma levels of IGFBP-1 are associated with pancreatic cancer risk, we did a prospective, case-control study nested within the Health Professionals Follow-up Study, the Nurses' Health Study, the Physicians' Health Study, and the Women's Health Initiative. We assayed circulating IGFBP-1 among 144 pancreatic cancer cases that occurred >or=4 years after plasma collection and in 429 controls, matched for date of birth, prospective cohort, smoking status, and fasting status. When compared with participants in the three highest quartiles of plasma IGFBP-1, those in the lowest quartile experienced a relative risk (RR) for pancreatic cancer of 2.07 [95% confidence intervals (95% CI), 1.26-3.39], after adjusting for other risk factors, including circulating IGF-I, IGF binding protein-3, and C-peptide. Only participants in the lowest quartile of plasma IGFBP-1 showed an elevated risk of pancreatic cancer. The influence of low plasma IGFBP-1 became progressively stronger with time; among cases diagnosed >or=8 years after blood collection, the adjusted RR was 3.47 (95% CI, 1.48-8.14), comparing the bottom versus the top three quartiles. The influence of plasma IGFBP-1 was most marked among participants who never smoked cigarettes (RR, 3.30; 95% CI, 1.48-7.35). Among participants in four U.S. prospective cohort studies, low plasma IGFBP-1 levels significantly predicted an increased risk of pancreatic cancer.

Circulating insulin-like growth factor binding protein-1 and the risk of pancreatic cancer. Publishing Authors By Initials

BM Wolpin,DS Michaud,EL Giovannucci,ES Schernhammer,MJ Stampfer,JE Manson,BB Cochrane,TE Rohan,J Ma,MN Pollak,CS Fuchs,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

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Circulating insulin-like growth factor binding protein-1 and the risk of pancreatic cancer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer research

VOLUME: 67

Page Numbers: 7923-8

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 15

MONTH: Aug

YEAR: 2007

Circulating insulin-like growth factor binding protein-1 and the risk of pancreatic cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984705

Circulating insulin-like growth factor binding protein-1 and the risk of pancreatic cancer. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: blood

Chemical & Substance for Abstract: Circulating insulin-like growth factor binding protein-1 and the risk of pancreatic cancer. Information

Substance Name: Insulin-Like Growth Factor Binding Prote

Registry Number: 0

Grant and Affiliation Information for Circulating insulin-like growth factor binding protein-1 and the risk of pancreatic cancer.

AFFILIATION: Department of Medical Oncology, Dana-Farber Cancer Institute, MA 02115, USA. bwolpin@partners.org

Country: United States

AGENCY: United States NCI

GRANT: CA95589

ACRONYM: CA

MEDLINETA: Cancer Res

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