Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts.

Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts. Research Abstract Details 

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Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts. Abstract Text:

B M Wolpin,D S Michaud,E L Giovannucci,E S Schernhammer,M J Stampfer,J E Manson,B B Cochrane,T E Rohan,J Ma,M N Pollak,C S Fuchs,

Insulin-like growth factor (IGF)-I induces growth in pancreatic cancer cells and blockade of the IGF-I receptor has antitumour activity. The association of plasma IGF-I and IGF binding protein-3 (IGFBP-3) with pancreatic cancer risk has been investigated in two small studies, with conflicting results. We conducted a nested case-control study within four large, prospective cohorts to investigate whether prediagnostic plasma levels of IGF-I, IGF-II, and IGFBP-3 were associated with pancreatic cancer risk. Plasma levels in 212 cases and 635 matched controls were compared by conditional logistic regression, with adjustment for other known pancreatic cancer risk factors. No association was observed between plasma levels of IGF-I, IGF-II, or IGFBP-3 and incident diagnosis of pancreatic cancer. Relative risks for the highest vs the lowest quartile of IGF-I, IGF-II, and IGFBP-3 were 0.94 (95% confidence interval (CI), 0.60-1.48), 0.96 (95% CI, 0.61-1.52), and 1.21 (95% CI, 0.75-1.92), respectively. The relative risk for the molar ratio of IGF-I and IGFBP-3, a surrogate measure for free IGF-I, was 0.84 (95% CI, 0.54-1.31). Additionally, no association was noted in stratified analyses or when requiring longer follow-up. In four prospective cohorts, we found no association between the risk of pancreatic cancer and prediagnostic plasma levels of IGF-I, IGF-II, or IGFBP-3.

Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts. Publishing Authors By Initials

BM Wolpin,DS Michaud,EL Giovannucci,ES Schernhammer,MJ Stampfer,JE Manson,BB Cochrane,TE Rohan,J Ma,MN Pollak,CS Fuchs,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

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Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: British journal of cancer

VOLUME: 97

Page Numbers: 98-104

Journal Abbreviation: Br. J. Cancer

ISSN: 0007-0920

DAY: 29

MONTH: 05

YEAR: 2007

Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370635

Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: blood

Chemical & Substance for Abstract: Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts. Information

Substance Name: Insulin-Like Growth Factor II

Registry Number: 67763-97-7

Grant and Affiliation Information for Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts.

AFFILIATION: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. bwolpin@partners.org

Country: England

AGENCY: United States NCI

GRANT: CA95589

ACRONYM: CA

MEDLINETA: Br J Cancer

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