Circulating endothelial microparticles in acute ischemic stroke: a link to severity, lesion volume and outcome.

Circulating endothelial microparticles in acute ischemic stroke: a link to severity, lesion volume and outcome. Research Abstract Details 

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Circulating endothelial microparticles in acute ischemic stroke: a link to severity, lesion volume and outcome. Abstract Text:

J Simak,M P Gelderman,H Yu,V Wright,A E Baird,

BACKGROUND: Endothelial membrane microparticles (EMP) in plasma are elevated in several vascular diseases. OBJECTIVES: To test the hypothesis that EMP would be increased in patients with acute ischemic stroke and would correlate with stroke severity, brain lesion volume and outcome. PATIENTS AND METHODS: Forty-one patients were studied and divided into two groups based on the National Institutes of Health Stroke Scale (NIHSS) score: 20 patients with mild stroke (NIHSS score < 5) and 21 patients with moderate-severe stroke (NIHSS score > or = 5). Lesion volume was measured using diffusion-weighted magnetic resonance imaging and discharge outcome was based on the discharge Barthel and Rankin scores. Twenty-three age-matched control subjects were also studied. Using flow cytometry, endoglin-positive EMP: CD105+ CD41a-CD45- (E(+)EMP), specific endothelial EMP expressing VE-cadherin and endoglin: CD105+CD144+ (C(+)EMP), EMP expressing phosphatidylserine: CD105+PS+ CD41a- (PS(+)EMP) and EMP expressing ICAM-1: CD105+CD54+ CD45- (I(+)EMP) were analyzed. RESULTS: Significantly higher PS(+)EMP counts were observed in the group of acute ischemic stroke patients [median 59 (25th-75th percentile: 28-86) MP microL(-1)] relative to the controls [28 (14-36) MP microL(-1)] (P = 0.002). All four EMP phenotypes studied were elevated in the subgroup of moderate-severe stroke patients relative to the controls (all P < 0.05). In the patients with acute ischemic stroke three EMP phenotypes (E(+)EMP, PS(+)EMP and I(+)EMP) correlated significantly with brain lesion volume, with I(+)EMP (P = 0.002) showing the strongest correlation. Admission counts of C(+)EMP (P = 0.0003) and E(+)EMP (P = 0.003) correlated significantly with discharge clinical outcome. CONCLUSIONS: Certain circulating EMP phenotypes may be associated with severity, lesion volume and outcome of acute ischemic stroke. EMP analysis shows promising contribution to understanding stroke pathophysiology.

Circulating endothelial microparticles in acute ischemic stroke: a link to severity, lesion volume and outcome. Publishing Authors By Initials

J Simak,MP Gelderman,H Yu,V Wright,AE Baird,

For similar nervous system diseases: central nervous system diseases: brain diseases: cerebrovascular disorders: stroke research abstracts see: nervous system diseases: central nervous system diseases: brain diseases: cerebrovascular disorders: stroke research

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Circulating endothelial microparticles in acute ischemic stroke: a link to severity, lesion volume and outcome. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of thrombosis and haemostasis : JTH

VOLUME: 4

Page Numbers: 1296-302

Journal Abbreviation: J. Thromb. Haemost.

ISSN: 1538-7933

DAY: 30

MONTH: Jun

YEAR: 2006

Circulating endothelial microparticles in acute ischemic stroke: a link to severity, lesion volume and outcome. Information

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LANGUAGE: eng

NlmUniqueID: 101170508

Circulating endothelial microparticles in acute ischemic stroke: a link to severity, lesion volume and outcome. Keywords Mesh Terms:

KEYWORDS: Stroke

MESH TERMS: therapy

Chemical & Substance for Abstract: Circulating endothelial microparticles in acute ischemic stroke: a link to severity, lesion volume and outcome. Information

Substance Name: Intercellular Adhesion Molecule-1

Registry Number: 126547-89-5

Grant and Affiliation Information for Circulating endothelial microparticles in acute ischemic stroke: a link to severity, lesion volume and outcome.

AFFILIATION: Laboratory of Cellular Hematology, CBER, FDA, HFM-335, Rockville, MD 20852-1448, USA. jan.simak@fda.hhs.gov

Country: England

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MEDLINETA: J Thromb Haemost

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