Circulating CD34-positive cells provide a marker of vascular risk associated with cognitive impairment.

Circulating CD34-positive cells provide a marker of vascular risk associated with cognitive impairment. Research Abstract Details 

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Circulating CD34-positive cells provide a marker of vascular risk associated with cognitive impairment. Abstract Text:

Akihiko Taguchi,Tomohiro Matsuyama,Takayuki Nakagomi,Yoko Shimizu,Ryuzo Fukunaga,Yoshiaki Tatsumi,Hiroo Yoshikawa,Akie Kikuchi-Taura,Toshihiro Soma,Hiroshi Moriwaki,Kazuyuki Nagatsuka,David M Stern,Hiroaki Naritomi,

Maintenance of uninterrupted cerebral circulation is critical for neural homeostasis. The level of circulating CD34-positive (CD34(+)) cells has been suggested as an index of cerebrovascular health, although its relationship with cognitive function has not yet been defined. In a group of individuals with cognitive impairment, the level of circulating CD34(+) cells was quantified and correlated with clinical diagnoses. Compared with normal subjects, a significant decrease in circulating CD34(+) cells was observed in patients with vascular-type cognitive impairment, although no significant change was observed in patients with Alzheimer's-type cognitive impairment who had no evidence of cerebral ischemia. The level of cognitive impairment was inversely correlated with numbers of circulating CD34(+) cells in patients with vascular-type cognitive impairment, but not Alzheimer's type. We propose that the level of circulating CD34(+) cells provides a marker of vascular risk associated with cognitive impairment, and that differences in the pathobiology of Alzheimer's- and vascular-type cognitive impairment may be mirrored in levels of circulating CD34(+) cells in these patient populations.Journal of Cerebral Blood Flow & Metabolism (2008) 28, 445-449; doi:10.1038/sj.jcbfm.9600541; published online 8 August 2007.

Circulating CD34-positive cells provide a marker of vascular risk associated with cognitive impairment. Publishing Authors By Initials

A Taguchi,T Matsuyama,T Nakagomi,Y Shimizu,R Fukunaga,Y Tatsumi,H Yoshikawa,A Kikuchi-Taura,T Soma,H Moriwaki,K Nagatsuka,DM Stern,H Naritomi,

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Circulating CD34-positive cells provide a marker of vascular risk associated with cognitive impairment. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of cerebral blood flow and metabolism : of

VOLUME: 28

Page Numbers: 445-9

Journal Abbreviation: J. Cereb. Blood Flow Metab.

ISSN: 0271-678X

DAY: 8

MONTH: 08

YEAR: 2007

Circulating CD34-positive cells provide a marker of vascular risk associated with cognitive impairment. Information

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LANGUAGE: eng

NlmUniqueID: 8112566

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AFFILIATION: 1Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan.

Country: United States

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MEDLINETA: J Cereb Blood Flow Metab

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