Circulating apelin concentrations in mother/infant pairs at term.

Circulating apelin concentrations in mother/infant pairs at term. Research Abstract Details 

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Circulating apelin concentrations in mother/infant pairs at term. Abstract Text:

Ariadne Malamitsi-Puchner,Dimitrios Gourgiotis,Maria Boutsikou,Stavroula Baka,Dimitrios Hassiakos,Despina D Briana,Ariadne Malamitsi-Puchner,Dimitrios Gourgiotis,Maria Boutsikou,Stavroula Baka,Dimitrios Hassiakos,Despina D Briana,Ariadne Malamitsi-Puchner,Dimitrios Gourgiotis,Maria Boutsikou,Stavroula Baka,Dimitrios Hassiakos,Despina D Briana,

Aim: To prospectively investigate circulating concentrations of the adipokine and angiogenic factor apelin in mother/infant pairs and correlate them with respective insulin concentrations. Methods: Plasma apelin concentrations were determined in 40 mothers and their singleton full-term foetuses and neonates on day 1 (N1) and 4 (N4) of life. Results: Maternal apelin concentrations were lower compared to foetal, N1 and N4 ones (p < 0.001 in all cases). N1 apelin concentrations were lower compared to foetal and N4 ones (p = 0.002 and p = 0.005, respectively). Maternal apelin concentrations positively correlated with foetal, N1 and N4 concentrations (r= 0.663, p < 0.001, r= 0.486, p = 0.003, r= 0.484, p = 0.003, respectively). Foetal apelin concentrations positively correlated with N1 and N4 ones (r= 0.337, p = 0.044 and r= 0.574, p < 0.001, respectively). N1 apelin concentrations positively correlated with N4 ones (r= 0.513, p = 0.001). No association was found between apelin concentrations and birthweight, gender, parity or mode of delivery. No significant correlations were observed between apelin and insulin concentrations. Conclusions: Concentrations of apelin are high in the foetus, possibly suggesting its potential role in intrauterine development. Apelin expression in placental tissue could account for its higher foetal concentrations and for its down-regulation soon after birth. The postnatal increase of apelin concentrations could presumably point to a gradual initiation of ex utero angiogenesis.

Circulating apelin concentrations in mother/infant pairs at term. Publishing Authors By Initials

A Malamitsi-Puchner,D Gourgiotis,M Boutsikou,S Baka,D Hassiakos,DD Briana,A Malamitsi-Puchner,D Gourgiotis,M Boutsikou,S Baka,D Hassiakos,DD Briana,A Malamitsi-Puchner,D Gourgiotis,M Boutsikou,S Baka,D Hassiakos,DD Briana,

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Circulating apelin concentrations in mother/infant pairs at term. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta paediatrica (Oslo, Norway : 1992)

VOLUME: 96

Page Numbers: 1751-4

Journal Abbreviation: Acta Paediatr.

ISSN: 0803-5253

DAY: 16

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 9205968

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AFFILIATION: Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece.

Country: Norway

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MEDLINETA: Acta Paediatr

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