Circulating activated T lymphocytes in autoeczematization.

Circulating activated T lymphocytes in autoeczematization. Research Abstract Details 

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Circulating activated T lymphocytes in autoeczematization. Abstract Text:

BACKGROUND AND DESIGN--Autoeczematization, the symmetric diffuse spread of a previously localized dermatitis, has an unclear etiology although some investigators have postulated that activated T lymphocytes play a role. Two estimates of activation of peripheral T lymphocytes are the cell surface expression of the HLA-DR antigen and the interleukin 2 receptor (IL-2R). We measured the percentage of circulating activated T lymphocytes in nine patients with autoeczematization compared with normal controls (n = 10), patients with stasis dermatitis (n = 6), and patients with severe (n = 10) or mild (n = 8) psoriasis. The percentage of activated T lymphocytes was determined by fluorescent, activated cell sorter analysis of peripheral leukocytes doubly stained with antibodies to T lymphocytes and HLA-DR antigen or IL-2R. RESULTS--Statistically significant elevations of HLA-DR- and IL-2R--positive T lymphocytes were seen in autoeczematization patients (P less than .004 and P less than .04, respectively) and those with severe psoriasis (P less than .004 for HLA-DR antigen and IL-2R). Percentages of HLA-DR- and IL-2R--positive T lymphocytes in patients with mild psoriasis were not significantly elevated. Two patients with autoeczematization had a reduction of their previously elevated levels of HLA-DR- and IL-2R--positive T lymphocytes after treatment. CONCLUSIONS--These data suggest a possible role for circulating activated T lymphocytes in the pathogenesis of autoeczematization and possibly in severe psoriasis.

Circulating activated T lymphocytes in autoeczematization. Publishing Authors By Initials

For similar cardiovascular diseases: vascular diseases: venous insufficiency research abstracts see: cardiovascular diseases: vascular diseases: venous insufficiency research

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Circulating activated T lymphocytes in autoeczematization. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Archives of dermatology

VOLUME: 128

Page Numbers: 795-8

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Jun

YEAR: 1992

Circulating activated T lymphocytes in autoeczematization. Information

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LANGUAGE: eng

NlmUniqueID: 372433

Circulating activated T lymphocytes in autoeczematization. Keywords Mesh Terms:

KEYWORDS: Venous Insufficiency

MESH TERMS: immunology

Chemical & Substance for Abstract: Circulating activated T lymphocytes in autoeczematization. Information

Substance Name: Tetanus Toxoid

Registry Number: 0

Grant and Affiliation Information for Circulating activated T lymphocytes in autoeczematization.

AFFILIATION: Department of Internal Medicine, Salt Lake City Veterans Affairs Medical Center, UT.

Country: UNITED STATES

AGENCY: United States NCRR

GRANT: M01-RR00064

ACRONYM: RR

MEDLINETA: Arch Dermatol

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