Circadian rhythm generation and entrainment in astrocytes.

Circadian rhythm generation and entrainment in astrocytes. Research Abstract Details 

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Circadian rhythm generation and entrainment in astrocytes. Abstract Text:

Laura M Prolo,Joseph S Takahashi,Erik D Herzog,

In mammals, the master circadian pacemaker is considered the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN consists of a heterogeneous population of neurons and relatively understudied glia. We investigated whether glia, like neurons, rhythmically express circadian genes. We generated pure cultures of cortical astrocytes from Period2::luciferase (Per2::luc) knock-in mice and Period1::luciferase (Per1::luc) transgenic rats and recorded bioluminescence as a real-time reporter of gene activity. We found that rat Per1::luc and mouse Per2::luc astroglia express circadian rhythms with a genetically determined period. These rhythms damped out after several days but were reinitiated by a variety of treatments, including a full volume exchange of the medium. If cultures were treated before damping out, the phase of Per1::luc rhythmicity was shifted, depending on the time of the pulse relative to the peak of Per1 expression. Glial rhythms entrained to daily 1.5 degrees C temperature cycles and were significantly sustained when cocultured with explants of the adult SCN but not with cortical explants. Thus, multiple signals, including a diffusible factor(s) from the SCN, are sufficient to either entrain or restart circadian oscillations in cortical glia.

Circadian rhythm generation and entrainment in astrocytes. Publishing Authors By Initials

LM Prolo,JS Takahashi,ED Herzog,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Circadian rhythm generation and entrainment in astrocytes. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of neuroscience : the official journal

VOLUME: 25

Page Numbers: 404-8

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 12

MONTH: Jan

YEAR: 2005

Circadian rhythm generation and entrainment in astrocytes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8102140

Circadian rhythm generation and entrainment in astrocytes. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Circadian rhythm generation and entrainment in astrocytes. Information

Substance Name: Luciferases

Registry Number: EC 1.13.12.-

Grant and Affiliation Information for Circadian rhythm generation and entrainment in astrocytes.

AFFILIATION: Department of Biology, Washington University, St. Louis, Missouri 63130-4899, USA.

Country: United States

AGENCY: United States NIMH

GRANT: MH63104

ACRONYM: MH

MEDLINETA: J Neurosci

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