Circadian organization of tau mutant hamsters: aftereffects and splitting.

Circadian organization of tau mutant hamsters: aftereffects and splitting. Research Abstract Details 

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Circadian organization of tau mutant hamsters: aftereffects and splitting. Abstract Text:

Eric L Bittman,Mary K Costello,Judy McKinley Brewer,Eric L Bittman,Mary K Costello,Judy McKinley Brewer,

Homozygous tau mutant (tau(ss)) hamsters show an extremely short (20 h) circadian period (tau) that is attributable to altered enzymatic activity of casein kinase 1epsilon. It has been proposed that coupling of constituent circadian oscillators is strengthened in tau(ss) hamsters, explaining their tendency to show strong resetting after prolonged exposure to constant darkness. To evaluate further the circadian organization of tau(ss) hamsters, the authors assessed the extent of shortening of period as an aftereffect of exposure to light:dark cycles whose period (T) is 91% of tau and the ability of constant light to induce splitting. They find that tau(ss) hamsters show aftereffects comparable to wild types, indicating that normal CK1epsilon activity is not required for T cycles to shorten tau. This finding also contradicts the proposal that circadian period is homeostatically conserved. However, the authors find that tau(ss) hamsters rarely show splitting in constant light. Furthermore, LL does not induce lengthening of tau or reduction of activity duration (alpha) in these mutants. The authors' findings support the conclusion that the tau mutation alters the coupling between constituent circadian oscillators.

Circadian organization of tau mutant hamsters: aftereffects and splitting. Publishing Authors By Initials

EL Bittman,MK Costello,JM Brewer,EL Bittman,MK Costello,JM Brewer,

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Circadian organization of tau mutant hamsters: aftereffects and splitting. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of biological rhythms

VOLUME: 22

Page Numbers: 425-31

Journal Abbreviation: J. Biol. Rhythms

ISSN: 0748-7304

DAY: 18

MONTH: Oct

YEAR: 2007

Circadian organization of tau mutant hamsters: aftereffects and splitting. Information

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LANGUAGE: eng

NlmUniqueID: 8700115

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Grant and Affiliation Information for Circadian organization of tau mutant hamsters: aftereffects and splitting.

AFFILIATION: Department of Biology and Program in Neuroscience and Behavior, University of Massachusetts, Amherst, MA 01003, USA. elb@bio.umass.edu

Country: United States

AGENCY: United States NIMH

GRANT: R01 MH 070019

ACRONYM: MH

MEDLINETA: J Biol Rhythms

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