Circadian expression of period 1, period 2, and arylalkylamine N-acetyltransferase mRNA in the rat pineal gland under different light conditions.

Circadian expression of period 1, period 2, and arylalkylamine N-acetyltransferase mRNA in the rat pineal gland under different light conditions. Research Abstract Details 

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Circadian expression of period 1, period 2, and arylalkylamine N-acetyltransferase mRNA in the rat pineal gland under different light conditions. Abstract Text:

C Fukuhara,J C Dirden,G Tosini,

Period 1 (Per1), 2 (Per2) and arylalkylamine N-acetyltransferase (AA-NAT) mRNA levels were determined by semi-quantitative in situ hybridization in rat pineal glands. In agreement with previous reports, AA-NAT mRNA levels were rhythmic in light:dark (LD) cycles and the rhythm persisted in constant dim light (DLL). Per1 and Per2 mRNA also showed significant variations both in LD and DLL. AA-NAT and Per1 mRNA levels showed very similar patterns of variations in LD and DLL to one another, whereas Per2 showed a different pattern of expression from AA-NAT and Per1. Exposure to 30 min of light did not affect the expression of the three genes, while exposure to a longer light pulse (1 or 2 h) decreased AA-NAT and Per1 mRNA levels; Per2 mRNA levels were also decreased but only temporarily. Our results demonstrate that Per1 and Per2 expression in the rat pineal is under circadian control, and suggest Per1 may be regulated by the same mechanism which controls the expression of AA-NAT gene. Per2 seem to be controlled by a different mechanism.

Circadian expression of period 1, period 2, and arylalkylamine N-acetyltransferase mRNA in the rat pineal gland under different light conditions. Publishing Authors By Initials

C Fukuhara,JC Dirden,G Tosini,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Circadian expression of period 1, period 2, and arylalkylamine N-acetyltransferase mRNA in the rat pineal gland under different light conditions. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Neuroscience letters

VOLUME: 286

Page Numbers: 167-70

Journal Abbreviation: Neurosci. Lett.

ISSN: 0304-3940

DAY: 9

MONTH: Jun

YEAR: 2000

Circadian expression of period 1, period 2, and arylalkylamine N-acetyltransferase mRNA in the rat pineal gland under different light conditions. Information

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LANGUAGE: eng

NlmUniqueID: 7600130

Circadian expression of period 1, period 2, and arylalkylamine N-acetyltransferase mRNA in the rat pineal gland under different light conditions. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Circadian expression of period 1, period 2, and arylalkylamine N-acetyltransferase mRNA in the rat pineal gland under different light conditions. Information

Substance Name: Arylamine N-Acetyltransferase

Registry Number: EC 2.3.1.5

Grant and Affiliation Information for Circadian expression of period 1, period 2, and arylalkylamine N-acetyltransferase mRNA in the rat pineal gland under different light conditions.

AFFILIATION: Neuroscience Institute, Morehouse School of Medicine, 720 Westview Drive, SW, GA 30310-1495, Atlanta, USA.

Country: IRELAND

AGENCY: United States NINDS

GRANT: NS 38483

ACRONYM: NS

MEDLINETA: Neurosci Lett

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