Cimetidine use and the risk for prostate cancer: results from the VITAL cohort study.

Cimetidine use and the risk for prostate cancer: results from the VITAL cohort study. Research Abstract Details 

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Cimetidine use and the risk for prostate cancer: results from the VITAL cohort study. Abstract Text:

Christine M Velicer,Sascha Dublin,Emily White,

PURPOSE: The histamine-2 (H(2)) blocker cimetidine may alter androgen, zinc, and prolactin levels, which could alter prostate cancer risk. Increased risk for men filling more than 20 cimetidine prescriptions was reported previously. We examined the association between cimetidine use and prostate cancer risk in a cohort in western Washington State. METHODS: Participants were 33,506 men, 50 to 76 years old, enrolled in the VITamins And Lifestyle cohort (VITAL). H(2)-blocker use during the prior 10 years was self-reported through baseline questionnaire between October 2000 and December 2002. Men were followed up for subsequent prostate cancer by linkage to the Surveillance, Epidemiology and End Results cancer registry. We identified 548 incident invasive prostate cancer cases diagnosed from baseline to December 31, 2003. RESULTS: Overall, no association between ever use of cimetidine or years of cimetidine use and prostate cancer risk was observed. However, daily cimetidine use for 10 years was associated with increased risk (relative risk, 2.35; 95% confidence interval, 1.05-5.26) compared with nonuse of any H(2) blockers. Use of other H(2) blockers was not associated with prostate cancer. CONCLUSIONS: Additional studies are needed to determine whether long-term daily cimetidine use is associated with increased prostate cancer risk in other populations, and if so, the reason for this association.

Cimetidine use and the risk for prostate cancer: results from the VITAL cohort study. Publishing Authors By Initials

CM Velicer,S Dublin,E White,

For similar geographic locations: americas: north america: united states: northwestern united states: washington research abstracts see: geographic locations: americas: north america: united states: northwestern united states: washington research

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Cimetidine use and the risk for prostate cancer: results from the VITAL cohort study. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Annals of epidemiology

VOLUME: 16

Page Numbers: 895-900

Journal Abbreviation:

ISSN: 1047-2797

DAY: 12

MONTH: 07

YEAR: 2006

Cimetidine use and the risk for prostate cancer: results from the VITAL cohort study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9100013

Cimetidine use and the risk for prostate cancer: results from the VITAL cohort study. Keywords Mesh Terms:

KEYWORDS: Washington

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Cimetidine use and the risk for prostate cancer: results from the VITAL cohort study. Information

Substance Name: Cimetidine

Registry Number: 51481-61-9

Grant and Affiliation Information for Cimetidine use and the risk for prostate cancer: results from the VITAL cohort study.

AFFILIATION: Department of Epidemiology, University of Washington, Seattle, WA 98195, USA. cvelicer@u.washington.edu

Country: United States

AGENCY: United States NCI

GRANT: T32CA09168

ACRONYM: CA

MEDLINETA: Ann Epidemiol

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