Cigarette smoking impairs bradykinin-stimulated tissue plasminogen activator release in human coronary circulation.

Cigarette smoking impairs bradykinin-stimulated tissue plasminogen activator release in human coronary circulation. Research Abstract Details 

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Cigarette smoking impairs bradykinin-stimulated tissue plasminogen activator release in human coronary circulation. Abstract Text:

Hiroyuki Takashima,Tetsuya Matsumoto,Ichiro Nakae,Tetsunobu Yamane,Minoru Horie,

BACKGROUND: Cigarette smoking is a major risk factor for acute coronary thrombosis. Bradykinin (BK) can induce the release of tissue plasminogen activator (tPA) from the coronary vasculature. The purpose of this study was to investigate whether smoking reduces BK-stimulated tPA release in human coronary circulation. MATERIALS AND METHODS: We examined two groups: 20 current smokers and 19 nonsmokers. By cardiac catheterization, graded doses of BK (0.2, 0.6 and 2.0 microg/min) and papaverine (PA) (12 mg) were administered into the coronary artery. Coronary blood flow (CBF) was measured using a Doppler flow wire. Blood samples from the aorta (Ao) and coronary sinus (CS) were assayed. RESULTS: BK increased both coronary artery diameter (CD) and CBF to a similar extent in the two groups. The net coronary tPA release was dose-dependently increased by BK in the two groups, but the degree of this increase in current smokers was significantly lower than that in nonsmokers. BK did not change plasminogen activator inhibitor type 1 (PAI 1) levels in either group. PA did not alter either tPA or PAI-1 levels in either group. CONCLUSIONS: These results suggest that cigarette smoking deteriorates coronary fibrolytic activity, independent of changes in CBF. These findings can at least partly explain the higher risk of coronary thrombosis in smokers.

Cigarette smoking impairs bradykinin-stimulated tissue plasminogen activator release in human coronary circulation. Publishing Authors By Initials

H Takashima,T Matsumoto,I Nakae,T Yamane,M Horie,

For similar chemical actions and uses: pharmacologic actions: therapeutic uses: cardiovascular agents: vasodilator agents research abstracts see: chemical actions and uses: pharmacologic actions: therapeutic uses: cardiovascular agents: vasodilator agents research

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Cigarette smoking impairs bradykinin-stimulated tissue plasminogen activator release in human coronary circulation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Thrombosis research

VOLUME: 120

Page Numbers: 791-6

Journal Abbreviation: Thromb. Res.

ISSN: 0049-3848

DAY: 27

MONTH: 02

YEAR: 2007

Cigarette smoking impairs bradykinin-stimulated tissue plasminogen activator release in human coronary circulation. Information

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LANGUAGE: eng

NlmUniqueID: 326377

Cigarette smoking impairs bradykinin-stimulated tissue plasminogen activator release in human coronary circulation. Keywords Mesh Terms:

KEYWORDS: Vasodilator Agents

MESH TERMS: metabolism

Chemical & Substance for Abstract: Cigarette smoking impairs bradykinin-stimulated tissue plasminogen activator release in human coronary circulation. Information

Substance Name: Tissue Plasminogen Activator

Registry Number: EC 3.4.21.68

Grant and Affiliation Information for Cigarette smoking impairs bradykinin-stimulated tissue plasminogen activator release in human coronary circulation.

AFFILIATION: Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta, Otsu 520-2192, Japan.

Country: United States

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MEDLINETA: Thromb Res

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