Chymopapain chemonucleolysis: correlation of diagnostic radiographic factors and clinical outcome.

Chymopapain chemonucleolysis: correlation of diagnostic radiographic factors and clinical outcome. Research Abstract Details 

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Chymopapain chemonucleolysis: correlation of diagnostic radiographic factors and clinical outcome. Abstract Text:

L R Gentry,C M Strother,P A Turski,M J Javid,J F Sackett,

The therapeutic response to treatment of lumbar disk herniation with chymopapain chemonucleolysis is significantly influenced by the criteria used for patient selection. Although careful clinical selection of patients reduces the frequency of treatment failure, some patients do not achieve satisfactory relief of pain with chemonucleolysis. In an attempt to identify objective pretreatment radiographic findings that might refine selection criteria and further reduce the failure rate of chemonucleolysis, a retrospective correlation of pretreatment radiographs and clinical responses was made of 200 consecutive chemonucleolysis patients. Marked improvement in sciatica occurred in 79.9% and 79.3% of patients at early and late follow-up, respectively. There was a significantly higher response rate, however, in patients who had definite radiographic evidence of focal disk herniation and in those patients with definite radiographic evidence of nerve-root compression (marked nerve-root deviation, nerve-root flattening or edema, root-sleeve amputation) by disk material. Those patients with a preinjection disk height greater than the mean had a slightly better response rate (91.1%) than those whose disk height was smaller than the mean (80.0%). Most cases of treatment failure could be attributed to an incorrect radiographic diagnosis, treatment of patients with equivocal diagnostic studies, the presence of "free" disk fragments, and causes of nerve-root compression unresponsive to chymopapain.

Chymopapain chemonucleolysis: correlation of diagnostic radiographic factors and clinical outcome. Publishing Authors By Initials

LR Gentry,CM Strother,PA Turski,MJ Javid,JF Sackett,

For similar diagnosis: prognosis research abstracts see: diagnosis: prognosis research

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Chymopapain chemonucleolysis: correlation of diagnostic radiographic factors and clinical outcome. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: AJR. American journal of roentgenology

VOLUME: 145

Page Numbers: 351-60

Journal Abbreviation:

ISSN: 0361-803X

DAY: 15

MONTH: Aug

YEAR: 1985

Chymopapain chemonucleolysis: correlation of diagnostic radiographic factors and clinical outcome. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7708173

Chymopapain chemonucleolysis: correlation of diagnostic radiographic factors and clinical outcome. Keywords Mesh Terms:

KEYWORDS: Prognosis

MESH TERMS: radiography

Chemical & Substance for Abstract: Chymopapain chemonucleolysis: correlation of diagnostic radiographic factors and clinical outcome. Information

Substance Name: Chymopapain

Registry Number: EC 3.4.22.6

Grant and Affiliation Information for Chymopapain chemonucleolysis: correlation of diagnostic radiographic factors and clinical outcome.

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Country: UNITED STATES

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MEDLINETA: AJR Am J Roentgenol

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