Chronic St. Louis encephalitis virus infection in the golden hamster (Mesocricetus auratus).

Chronic St. Louis encephalitis virus infection in the golden hamster (Mesocricetus auratus). Research Abstract Details 

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Chronic St. Louis encephalitis virus infection in the golden hamster (Mesocricetus auratus). Abstract Text:

Marina T Siirin,Tao Duan,Hao Lei,Hilda Guzman,Amelia P A Travassos da Rosa,Douglas M Watts,Shu-Yuan Xiao,Robert B Tesh,

To further study the phenomenon of flavivirus persistent infection, golden hamsters (Mesocricetus auratus) were inoculated intraperitoneally with a low pathogenicity strain of St. Louis encephalitis virus (SLEV). After inoculation, the animals remained asymptomatic and developed high levels of specific neutralizing antibodies in their sera. However, about one half of the hamsters continued to shed infectious SLEV in their urine for prolonged periods of time. By co-cultivation, SLEV was recovered from selected tissues (kidney, lung, and brain) of some of the animals for up to 185 days after initial infection. Although no specific histopathologic changes were observed in these tissues, SLEV antigen was shown by immunohistochemistry in the interstitium and tubular epithelium of the renal cortex and in a few large neurons of the cerebral cortex. Seventeen SLEV isolates from urine and tissues of the chronically infected hamsters were sequenced. In comparison with the infecting parent SLEV strain, two common mutations and amino acid substitutions were observed in all of the hamster isolates. The findings of this study were very similar to previous descriptions of chronic West Nile, Modoc, and tick-borne encephalitis virus infections in mammals, and they re-emphasize the potential importance of persistent flavivirus infection in vertebrates.

Chronic St. Louis encephalitis virus infection in the golden hamster (Mesocricetus auratus). Publishing Authors By Initials

MT Siirin,T Duan,H Lei,H Guzman,AP da Rosa,DM Watts,SY Xiao,RB Tesh,

For similar investigative techniques: genetic techniques: sequence analysis: sequence analysis, dna research abstracts see: investigative techniques: genetic techniques: sequence analysis: sequence analysis, dna research

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Chronic St. Louis encephalitis virus infection in the golden hamster (Mesocricetus auratus). Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The American journal of tropical medicine and hygi

VOLUME: 76

Page Numbers: 299-306

Journal Abbreviation: Am. J. Trop. Med. Hyg.

ISSN: 0002-9637

DAY: 3

MONTH: Feb

YEAR: 2007

Chronic St. Louis encephalitis virus infection in the golden hamster (Mesocricetus auratus). Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370507

Chronic St. Louis encephalitis virus infection in the golden hamster (Mesocricetus auratus). Keywords Mesh Terms:

KEYWORDS: Sequence Analysis, DNA

MESH TERMS: genetics

Chemical & Substance for Abstract: Chronic St. Louis encephalitis virus infection in the golden hamster (Mesocricetus auratus). Information

Substance Name: RNA, Viral

Registry Number: 0

Grant and Affiliation Information for Chronic St. Louis encephalitis virus infection in the golden hamster (Mesocricetus auratus).

AFFILIATION: Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas 77555-0609, USA.

Country: United States

AGENCY: United States NIAID

GRANT: N01-AI30027

ACRONYM: AI

MEDLINETA: Am J Trop Med Hyg

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