Chronic oral physostigmine without lecithin improves memory in Alzheimer's disease.

Chronic oral physostigmine without lecithin improves memory in Alzheimer's disease. Research Abstract Details 

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Chronic oral physostigmine without lecithin improves memory in Alzheimer's disease. Abstract Text:

Sixteen patients with early Alzheimer's disease (AD) completed a 3-month outpatient double-blind parallel trial of oral physostigmine versus placebo. Ten subjects received drug; six received placebo. After a dose-titration phase, each patient was placed on his or her best dose of drug or placebo. Subjects were evaluated with both memory and nonmemory tasks. Seven of the ten drug-treated patients, but none of the six placebo-treated patients, demonstrated improvement on a selective reminding task, a test of verbal memory. Family members reported improvement in six of ten drug-treated patients and none of six placebo-treated individuals. There was a trend toward greater improvement with increasing drug dose. There was no improvement on the nonmemory tests administered. The data indicate that oral physostigmine improves memory but not other areas of cognition.

Chronic oral physostigmine without lecithin improves memory in Alzheimer's disease. Publishing Authors By Initials

For similar behavioral disciplines and activities: psychological tests research abstracts see: behavioral disciplines and activities: psychological tests research

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Chronic oral physostigmine without lecithin improves memory in Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of the American Geriatrics Society

VOLUME: 37

Page Numbers: 42-8

Journal Abbreviation: J Am Geriatr Soc

ISSN: 0002-8614

DAY: 10

MONTH: Jan

YEAR: 1989

Chronic oral physostigmine without lecithin improves memory in Alzheimer's disease. Information

Number of References: 62

LANGUAGE: eng

NlmUniqueID: 7503062

Chronic oral physostigmine without lecithin improves memory in Alzheimer's disease. Keywords Mesh Terms:

KEYWORDS: Psychological Tests

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Chronic oral physostigmine without lecithin improves memory in Alzheimer's disease. Information

Substance Name: Physostigmine

Registry Number: 57-47-6

Grant and Affiliation Information for Chronic oral physostigmine without lecithin improves memory in Alzheimer's disease.

AFFILIATION: Neurology Service, San Diego VA Medical Center, CA 92161.

Country: UNITED STATES

AGENCY: United States NIA

GRANT: AGO 5386

ACRONYM: AG

MEDLINETA: J Am Geriatr Soc

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