Chronic ocular hypertension induces dendrite pathology in the lateral geniculate nucleus of the brain.

Chronic ocular hypertension induces dendrite pathology in the lateral geniculate nucleus of the brain. Research Abstract Details 

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Chronic ocular hypertension induces dendrite pathology in the lateral geniculate nucleus of the brain. Abstract Text:

Neeru Gupta,Tina Ly,Qiang Zhang,Paul L Kaufman,Robert N Weinreb,Yeni H ,

In glaucoma, there is atrophy and loss of retinal ganglion cells (RGC), in addition to atrophy and loss of target neurons in the lateral geniculate nucleus (LGN) of the brain. To investigate possible changes to the dendrites of LGN neurons in glaucoma, a selective marker for dendrites called microtubule-associated protein-2 (MAP2) was used. The LGNs from five monkeys with varying degrees of optic nerve fiber loss were compared to those from five normal control monkeys. Dendrites in magno- and parvocellular layers connected to the glaucomatous eye were evaluated. In controls, long MAP2-positive dendrites with multiple fine branches were seen. However, chronic ocular hypertension induced striking disruption of dendrites with a thickened and shortened appearance. Dendrite field area was significantly reduced in the glaucoma group compared to controls. Sholl analysis revealed reduced dendrite complexity by 47% and 41% in magnocellular layer 1 and parvocellular layer 6, respectively in the glaucoma group compared to controls. The striking dendrite changes in the LGN following chronically elevated intraocular pressure may be relevant to early visual dysfunction in glaucoma.

Chronic ocular hypertension induces dendrite pathology in the lateral geniculate nucleus of the brain. Publishing Authors By Initials

N Gupta,T Ly,Q Zhang,PL Kaufman,RN Weinreb,YH ,

For similar nervous system: peripheral nervous system: peripheral nerves: cranial nerves: optic nerve research abstracts see: nervous system: peripheral nervous system: peripheral nerves: cranial nerves: optic nerve research

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Chronic ocular hypertension induces dendrite pathology in the lateral geniculate nucleus of the brain. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental eye research

VOLUME: 84

Page Numbers: 176-84

Journal Abbreviation: Exp. Eye Res.

ISSN: 0014-4835

DAY: 7

MONTH: 11

YEAR: 2006

Chronic ocular hypertension induces dendrite pathology in the lateral geniculate nucleus of the brain. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370707

Chronic ocular hypertension induces dendrite pathology in the lateral geniculate nucleus of the brain. Keywords Mesh Terms:

KEYWORDS: Optic Nerve

MESH TERMS: pathology

Chemical & Substance for Abstract: Chronic ocular hypertension induces dendrite pathology in the lateral geniculate nucleus of the brain. Information

Substance Name: Microtubule-Associated Proteins

Registry Number: 0

Grant and Affiliation Information for Chronic ocular hypertension induces dendrite pathology in the lateral geniculate nucleus of the brain.

AFFILIATION: Glaucoma and Nerve Protection Unit, St. Michael's Hospital, University of Toronto, Canada.

Country: England

AGENCY: United States NEI

GRANT: EY02698

ACRONYM: EY

MEDLINETA: Exp Eye Res

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