Chronic nicotine self-administration augments hypothalamic-pituitary-adrenal responses to mild acute stress.

Chronic nicotine self-administration augments hypothalamic-pituitary-adrenal responses to mild acute stress. Research Abstract Details 

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Chronic nicotine self-administration augments hypothalamic-pituitary-adrenal responses to mild acute stress. Abstract Text:

Hao Chen,Yitong Fu,Burt M Sharp,

We investigated the effect of chronic nicotine self-administration (SA) on hypothalamic-pituitary-adrenal (HPA) hormonal responses to acute stressors. Adult male Sprague-Dawley rats were given access to nicotine (0.03 mg/kg) for 23 h per day for 20 days. On day 1 of acquisition of nicotine SA, plasma levels of both adrenocorticotropin and corticosterone were significantly increased 15-30 min after the first dose of nicotine. These hormonal changes were no longer significant on day 3, when adrenocorticotropin levels were <60 pg/ml and corticosterone levels were <110 ng/ml during the hour after the first dose of nicotine. Chronic nicotine SA (20 days) significantly augmented (2-3-fold) both hormonal responses to mild foot shock stress (0.6 mA, 0.5 s per shock, 5 shocks per 5 min), but did not affect hormonal responses to moderate shock (1.2 mA, 0.5 s per shock, 5 shocks per 5 min), lipopolysaccharide or immobilization. Similar data were obtained in Lewis rats. These results provide further support for the concept that chronic nicotine SA is a stressor. In alignment with the effects of other stressors, nicotine activated the HPA axis on the first day of SA, but desensitization occurred with repeated exposure. Furthermore, chronic nicotine SA selectively cross-sensitized the HPA response to a novel stressor. These observations suggest that nicotine may selectively increase the HPA response to stressors in human smokers.Neuropsychopharmacology (2008) 33, 721-730; doi:10.1038/sj.npp.1301466; published online 6 June 2007.

Chronic nicotine self-administration augments hypothalamic-pituitary-adrenal responses to mild acute stress. Publishing Authors By Initials

H Chen,Y Fu,BM Sharp,

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Chronic nicotine self-administration augments hypothalamic-pituitary-adrenal responses to mild acute stress. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuropsychopharmacology : official publication of

VOLUME: 33

Page Numbers: 721-30

Journal Abbreviation: Neuropsychopharmacology

ISSN: 0893-133X

DAY: 6

MONTH: 06

YEAR: 2007

Chronic nicotine self-administration augments hypothalamic-pituitary-adrenal responses to mild acute stress. Information

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LANGUAGE: eng

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AFFILIATION: 1Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN, USA.

Country: United States

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MEDLINETA: Neuropsychopharmacology

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