Chronic hypertension enhances the postsynaptic effect of baclofen in the nucleus tractus solitarius.

Chronic hypertension enhances the postsynaptic effect of baclofen in the nucleus tractus solitarius. Research Abstract Details 

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Chronic hypertension enhances the postsynaptic effect of baclofen in the nucleus tractus solitarius. Abstract Text:

Weirong Zhang,Myrna Herrera-Rosales,Steve Mifflin,

Microinjection of the inhibitory neurotransmitter gamma-aminobutyric acid B-subtype receptor agonist baclofen into the nucleus tractus solitarius increases arterial blood pressure and sympathetic nerve discharge. The baclofen-induced pressor response is enhanced in chronic hypertension. We hypothesized that a postsynaptic mechanism contributes to the enhanced responses to baclofen in hypertension. We investigated the postsynaptic effect of baclofen on second-order baroreceptor neurons, identified by 1,1'-dilinoleyl-3,3,3',3'-tetra-methylindocarbocyanine, 4-chlorobenzenesulphonate labeling of the aortic nerve, in nucleus tractus solitarius slices from sham-operated normotensive and unilateral nephrectomized, renal-wrap hypertensive rats. After 4 weeks, arterial blood pressure was 153+/-7 mm Hg in hypertensive rats (n=9) and 93+/-3 mm Hg in normotensive rats (n=8; P<0.05). There was no difference in resting membrane potential (54.5+/-0.7 versus 53.3+/-0.6 mV) or input resistance (1.07+/-0.11 versus 1.03+/-0.11 GOmega) between hypertensive and normotensive neurons (both n=18). Baclofen induced a net outward current in nucleus tractus solitarius neurons in the presence of 1 micromol/L tetrodotoxin. The EC50 of the baclofen effect was greater in normotensive cells (9.1+/-3.2 micromol/L; n=5) than hypertensive cells (3.0+/-0.5 micromol/L; n=7; P<0.05), and baclofen (10 micromol/L) induced a greater decrease in input resistance in hypertensive cells (61+/-2%; n=6) than in normotensive cells (45+/-4%; n=9; P<0.05). Both potassium and calcium channels were involved in the baclofen-evoked whole-cell current. The results suggest an enhanced postsynaptic response to activation of inhibitory neurotransmitter gamma-aminobutyric acid B-subtype receptors in second-order baroreceptor neurons in the nucleus tractus solitarius in renal-wrap hypertensive rats. This enhanced inhibition could alter baroreflex function in chronic hypertension.

Chronic hypertension enhances the postsynaptic effect of baclofen in the nucleus tractus solitarius. Publishing Authors By Initials

W Zhang,M Herrera-Rosales,S Mifflin,

For similar synaptic transmission research abstracts see: synaptic transmission research

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Chronic hypertension enhances the postsynaptic effect of baclofen in the nucleus tractus solitarius. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Hypertension

VOLUME: 49

Page Numbers: 659-63

Journal Abbreviation: Hypertension

ISSN: 1524-4563

DAY: 4

MONTH: 12

YEAR: 2006

Chronic hypertension enhances the postsynaptic effect of baclofen in the nucleus tractus solitarius. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7906255

Chronic hypertension enhances the postsynaptic effect of baclofen in the nucleus tractus solitarius. Keywords Mesh Terms:

KEYWORDS: Synaptic Transmission

MESH TERMS: drug effects

Chemical & Substance for Abstract: Chronic hypertension enhances the postsynaptic effect of baclofen in the nucleus tractus solitarius. Information

Substance Name: Baclofen

Registry Number: 1134-47-0

Grant and Affiliation Information for Chronic hypertension enhances the postsynaptic effect of baclofen in the nucleus tractus solitarius.

AFFILIATION: Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL-56637

ACRONYM: HL

MEDLINETA: Hypertension

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