Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice.

Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice. Abstract Text:

Robert Gyurko,Camille C Siqueira,Nathaniel Caldon,Li Gao,Alpdogan Kantarci,Thomas E Van Dyke,

The role of polymorphonuclear neutrophils (PMN) in mediating diabetic tissue damage to the periodontium was investigated in a novel model of chronic hyperglycemia, the Akita mouse. Induction of acute peritoneal inflammation in wild-type (WT) and Akita mice resulted in exaggerated IL-6 response in Akita mice (2.9-fold increase over WT values) and a markedly increased chemokine response (KC, 2.6-fold; MCP-1, 2.6-fold; and MIP-1alpha, 4.4-fold increase over WT values). Chemotaxis to both fMLP and WKYMVm was significantly reduced in isolated Akita PMN compared with WT PMN as measured in a Boyden chamber. Superoxide release in contrast was significantly increased in Akita PMN as measured with cytochrome c reduction. Bone marrow-derived Akita PMN showed partial translocation of p47phox to the cell membrane without external stimulation, suggesting premature assembly of the superoxide-producing NADPH oxidase in hyperglycemia. In vivo studies revealed that ligature-induced periodontal bone loss is significantly greater in Akita mice compared with WT. Moreover, intravital microscopy of gingival vessels showed that leukocyte rolling and attachment to the vascular endothelium is enhanced in periodontal vessels of Akita mice. These results indicate that chronic hyperglycemia predisposes to exaggerated inflammatory response and primes leukocytes for marginalization and superoxide production but not for transmigration. Thus, leukocyte defects in hyperglycemia may contribute to periodontal tissue damage by impairing the innate immune response to periodontal pathogens as well as by increasing free radical load in the gingival microvasculature.

Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice. Publishing Authors By Initials

R Gyurko,CC Siqueira,N Caldon,L Gao,A Kantarci,TE Van Dyke,

For similar beta-glucans: zymosan research abstracts see: beta-glucans: zymosan research

PUBMED ID PMID:

MEDLINE DATE:

Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 177

Page Numbers: 7250-6

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Nov

YEAR: 2006

Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice. Keywords Mesh Terms:

KEYWORDS: Zymosan

MESH TERMS: toxicity

Chemical & Substance for Abstract: Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice. Information

Substance Name: Zymosan

Registry Number: 9010-72-4

Grant and Affiliation Information for Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice.

AFFILIATION: Department of Periodontology and Oral Biology, Boston University, Boston, MA 02118, USA. gyurko@bu.edu

Country: United States

AGENCY: United States NIDCR

GRANT: DE16933

ACRONYM: DE

MEDLINETA: J Immunol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice Related Publications

• Activation of RAGE induces elevated O2- generation by mononuclear phagocytes in diabetes.
• CD38 cleavage in fMLP- and IL-8-induced chemotaxis is dependent on p38 MAP kinase but independent of p44/42 MAP kinase.
• Child with De Novo t(1;6)(p22.1;p22.1) translocation and features of ectodermal dysplasia with hypodontia and developmental delay.
• Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice.
• Clinical characteristics and microbiota of progressing slight chronic periodontitis in adults.
• Colon cancer: an update on screening.
• Detection of low level sex chromosome mosaicism in Ullrich-Turner syndrome patients.
• Effects of chlorpromazine and alcohol on coordination and judgement.
• Experimental aberrant mediastinal goiters (thymic) in the rat.
• Identifying genetic changes associated with tumor progression in squamous cell carcinoma.
• Inactivation of gadd45a Sensitizes Epithelial Cancer Cells to Ionizing Radiation In vivo Resulting in Prolonged Survival.
• Inferior lumbar (Petit's) hernia.
• Malignancy-associated vessel tortuosity: a computer-assisted, MR angiographic study of choroid plexus carcinoma in genetically engineered mice.
• New analgesic drugs.
• Oral infection, hyperglycemia, and endothelial dysfunction.
• Parthenolide specifically depletes histone deacetylase 1 protein and induces cell death through ataxia telangiectasia mutated.
• Peripheral blood cytogenetic studies in hematological neoplasms: predictors of obtaining metaphases for analysis.
• Persistent Bordetella bronchiseptica pneumonia in an immunocompetent infant and genetic comparison of clinical isolates with kennel cough vaccine strains.
• Phase I/II trial of intermittent subcutaneous IL-2 administration in pediatric patients with moderate immune suppression: results of Pediatric AIDS Clinical Trials Study 402.
• Radiobiology. NYO-2740-3.
• Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo.
• Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators.
• Six year audit of cardiac arrests and medical emergency team calls in an Australian outer metropolitan teaching hospital.
• Smart biomaterials design for tissue engineering and regenerative medicine.
• Synthetic analgesic drugs.
• The altered blood-pressure response after adrenolytic drugs and large doses of sympathomimetic amines.
• The link between periodontal disease and cardiovascular disease is probably inflammation.
• The metabolism of barbiturates.
• The use of keratin biomaterials derived from human hair for the promotion of rapid regeneration of peripheral nerves.
• Validity of demographically corrected norms for the WAIS-III.