Chronic food restriction: enhancing effects on drug reward and striatal cell signaling.

Chronic food restriction: enhancing effects on drug reward and striatal cell signaling. Research Abstract Details 

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Chronic food restriction: enhancing effects on drug reward and striatal cell signaling. Abstract Text:

Kenneth D Carr,

Chronic food restriction (FR) increases behavioral sensitivity to drugs of abuse in animal models and is associated with binge eating, which shares comorbidity with drug abuse, in clinical populations. Behavioral, biochemical and molecular studies conducted in this laboratory to elucidate the functional and mechanistic bases of these phenomena are briefly reviewed. Results obtained to date indicate that FR increases the reward magnitude and locomotor-activating effects of abused drugs, and direct dopamine (DA) receptor agonists, as a result of neuroadaptations rather than changes in drug disposition. Changes in striatal DA dynamics, and postsynaptic cell signaling and gene expression in response to D-1 DA receptor stimulation have been observed. Of particular interest is an upregulation of NMDA receptor-dependent MAP kinase and CaM Kinase II signaling, CREB phosphorylation, and immediate-early and neuropeptide gene expression in nucleus accumbens (NAc) which may facilitate reward-related learning, but also play a role in the genesis of maladaptive goal-directed behaviors. Covariation of altered drug reward sensitivity with body weight loss and recovery suggests a triggering role for one of the endocrine adiposity hormones. However, neither acute nor chronic central infusions of leptin or the melanocortin 3/4 receptor agonist, MTII, have attenuated d-amphetamine reward or locomotor activation in FR rats. Interestingly, chronic intracerebroventricular leptin infusion in ad libitum fed (AL) rats produced a sustained decrease in food intake and body weight that was accompanied by a reversible potentiation of rewarding and locomotor-activating effects of d-amphetamine. This raises the interesting possibility that rapid progressive weight loss is sufficient to increase behavioral sensitivity to drugs of abuse. Whether weight loss produced by leptin infusion produces the same neuroadaptations as experimenter-imposed FR, and whether any of the observed neuroadaptations are necessary for expression of increased behavioral responsiveness to acute drug challenge remain to be investigated.

Chronic food restriction: enhancing effects on drug reward and striatal cell signaling. Publishing Authors By Initials

KD Carr,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

PUBMED ID PMID:

MEDLINE DATE:

Chronic food restriction: enhancing effects on drug reward and striatal cell signaling. Journal Published:

PUBLICATION TYPE: Review

Journal: Physiology & behavior

VOLUME: 91

Page Numbers: 459-72

Journal Abbreviation: Physiol. Behav.

ISSN: 0031-9384

DAY: 1

MONTH: 11

YEAR: 2006

Chronic food restriction: enhancing effects on drug reward and striatal cell signaling. Information

Number of References: 136

LANGUAGE: eng

NlmUniqueID: 151504

Chronic food restriction: enhancing effects on drug reward and striatal cell signaling. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Chronic food restriction: enhancing effects on drug reward and striatal cell signaling. Information

Substance Name: Dopamine

Registry Number: 51-61-6

Grant and Affiliation Information for Chronic food restriction: enhancing effects on drug reward and striatal cell signaling.

AFFILIATION: Departments of Psychiatry and Pharmacology, Millhauser Laboratories, New York University School of Medicine, New York, NY 10016, USA. kc16@nyu.edu

Country: United States

AGENCY: United States NIDA

GRANT: K02 DA00292

ACRONYM: DA

MEDLINETA: Physiol Behav

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