Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration.

Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration. Abstract Text:

Deepinder Kaur,Subramanian Rajagopalan,Shankar Chinta,Jyothi Kumar,Donato Di Monte,Robert A Cherny,Julie K Andersen,

Ferritin elevation has been reported by some laboratories to occur within the substantia nigra (SN), the area of the brain affected in Parkinson's disease (PD), but whether such an increase could be causatively involved in neurodegeneration associated with the disorder is unknown. Here, we report that chronic ferritin elevation in midbrain dopamine-containing neurons results in a progressive age-related neurodegeneration of these cells. This provides strong evidence that chronic ferritin overload could be directly involved in age-related neurodegeneration such as occurs in Parkinson's and other related diseases.

Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration. Publishing Authors By Initials

D Kaur,S Rajagopalan,S Chinta,J Kumar,D Di Monte,RA Cherny,JK Andersen,

For similar enzymes and coenzymes: enzymes: oxidoreductases: oxygenases: mixed function oxygenases: tyrosine 3-monooxygenase research abstracts see: enzymes and coenzymes: enzymes: oxidoreductases: oxygenases: mixed function oxygenases: tyrosine 3-monooxygenase research

PUBMED ID PMID:

MEDLINE DATE:

Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Brain research

VOLUME: 1140

Page Numbers: 188-94

Journal Abbreviation: Brain Res.

ISSN: 0006-8993

DAY: 2

MONTH: 05

YEAR: 2006

Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 45503

Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration. Keywords Mesh Terms:

KEYWORDS: Tyrosine 3-Monooxygenase

MESH TERMS: metabolism

Chemical & Substance for Abstract: Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration. Information

Substance Name: Tyrosine 3-Monooxygenase

Registry Number: EC 1.14.16.2

Grant and Affiliation Information for Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration.

AFFILIATION: Buck Institute for Research in Aging, Novato, CA 94945, USA.

Country: Netherlands

AGENCY: United States NINDS

GRANT: NS41264

ACRONYM: NS

MEDLINETA: Brain Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration Related Publications

• 2,3-butanedione monoxime affects cystic fibrosis transmembrane conductance regulator channel function through phosphorylation-dependent and phosphorylation-independent mechanisms: the role of bilayer material properties.
• 494.
• A floating metal microelectrode array for chronic implantation.
• A new multi-site probe array with monolithically integrated parylene flexible cable for neural prostheses.
• Aluminium in peritoneal dialysis fluids as determined by stabilised temperature platform furnace atomic absorption spectrometry.
• Analysis of nucleolar protein dynamics reveals the nuclear degradation of ribosomal proteins.
• Body change stress for women with breast cancer: the Breast-Impact of Treatment Scale.
• Brain activity during stimulation of the trigeminal nerve with noxious heat.
• Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration.
• Deceptive simplicity: systemic oxygen delivery and pulse oximetry.
• Docosahexaenoic acid alters bilayer elastic properties.
• Graded semantic and phonological similarity effects in priming: evidence for a distributed connectionist approach to morphology.
• Hepatic sequestration of chlordecone and hexafluoroacetone evaluated by pharmacokinetic modeling.
• In vitro and in vivo neuroprotection by gamma-glutamylcysteine ethyl ester against MPTP: relevance to the role of glutathione in Parkinson's disease.
• Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age.
• Iron and paraquat as synergistic environmental risk factors in sporadic Parkinson's disease accelerate age-related neurodegeneration.
• Long-term follow-up comparison of durasphere and contigen in the treatment of stress urinary incontinence.
• Low cardiorespiratory fitness is a strong predictor for clustering of cardiovascular disease risk factors in children independent of country, age and sex.
• Mechanisms and emerging treatments of the metabolic complications of chronic pancreatitis.
• Meeting report: Sloan Foundation Workshop to resolve problems relating to the taxonomy of microorganisms and to culture collections arising from the barcoding initiatives; Portland ME, November 6-7, 2006.
• Moderators' summary: wound management (session I).
• Muscle fibre number varies with haemoglobin phenotype in Atlantic cod as predicted by the optimal fibre number hypothesis.
• Nine-year prediction of adolescent smoking by number of smoking parents.
• Reversible inhibition of mitochondrial complex I activity following chronic dopaminergic glutathione depletion in vitro: implications for Parkinson's disease.
• Social Inequalities in Level of Physical Activity and Overweight among 9-year old Children: 2603: Board #150 June 2 8:00 AM - 9:30 AM.
• Strategies used in coping with a cancer diagnosis predict meaning in life for survivors.
• Studies of the organization of the human nociceptive withdrawal reflex*.
• Survey of pesticide residues in table grapes: determination of processing factors, intake and risk assessment.
• The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4.
• The ground dominance effect in the perception of relative distance in 3-D scenes is mainly due to characteristics of the ground surface.