Chronic blockade of angiotensin II AT1-receptors increased cell-to-cell communication, reduced fibrosis and improved impulse propagation in the failing heart.

Chronic blockade of angiotensin II AT1-receptors increased cell-to-cell communication, reduced fibrosis and improved impulse propagation in the failing heart. Research Abstract Details 

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Chronic blockade of angiotensin II AT1-receptors increased cell-to-cell communication, reduced fibrosis and improved impulse propagation in the failing heart. Abstract Text:

Walmor C De Mello,Philip Specht,

INTRODUCTION: The influence of chronic administration of losartan on gap junction conductance (gj), conduction velocity and interstitial fibrosis was investigated in the failing heart of 4-month-old cardiomyopathic hamsters (TO-2). After two months of administration of losartan (25 mg/kg/day/po) the number of cell pairs showing very low values of gj (28 nS) was significantly reduced whereas the group of cell pairs with larger values of gj (18-45 nS) was significantly increased. The conduction velocity measured with intracellular microelectrodes in the wall of the left ventricle was enhanced from 38+2.3 cm/s (n=25) (control) to 49+2 cm/s (n=24) (p<0.05) after losartan administration. Moreover, the number of ventricular fibres showing non-propagated action potentials was significantly decreased (p<0.05) by losartan. The % area of interstitial fibrosis measured in the wall of the left ventricle was reduced from 22+1.4% (n=18) to 14+1.3% (n=18) (p<0.05) after losartan administration. CONCLUSION: Chronic blockade of angiotensin II type 1 receptors increased gj in the failing heart. Moreover, the conduction velocity was enhanced in part by the increase of gj and in part by the decrease of interstitial fibrosis and structural remodelling.

Chronic blockade of angiotensin II AT1-receptors increased cell-to-cell communication, reduced fibrosis and improved impulse propagation in the failing heart. Publishing Authors By Initials

WC De Mello,P Specht,

For similar musculoskeletal, neural, and ocular physiology: nervous system physiology: nervous system physiologic processes: neural conduction research abstracts see: musculoskeletal, neural, and ocular physiology: nervous system physiology: nervous system physiologic processes: neural conduction research

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Chronic blockade of angiotensin II AT1-receptors increased cell-to-cell communication, reduced fibrosis and improved impulse propagation in the failing heart. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of the renin-angiotensin-aldosterone syste

VOLUME: 7

Page Numbers: 201-5

Journal Abbreviation:

ISSN: 1470-3203

DAY: 3

MONTH: Dec

YEAR: 2006

Chronic blockade of angiotensin II AT1-receptors increased cell-to-cell communication, reduced fibrosis and improved impulse propagation in the failing heart. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100971636

Chronic blockade of angiotensin II AT1-receptors increased cell-to-cell communication, reduced fibrosis and improved impulse propagation in the failing heart. Keywords Mesh Terms:

KEYWORDS: Neural Conduction

MESH TERMS: drug effects

Chemical & Substance for Abstract: Chronic blockade of angiotensin II AT1-receptors increased cell-to-cell communication, reduced fibrosis and improved impulse propagation in the failing heart. Information

Substance Name: Losartan

Registry Number: 114798-26-4

Grant and Affiliation Information for Chronic blockade of angiotensin II AT1-receptors increased cell-to-cell communication, reduced fibrosis and improved impulse propagation in the failing heart.

AFFILIATION: Department of Pharmacology, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR 00936-5067, USA. wmello@rcm.upr.edu

Country: England

AGENCY: United States NHLBI

GRANT: HL 34148

ACRONYM: HL

MEDLINETA: J Renin Angiotensin Aldosteron

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