Chronic alcohol consumption perturbs the balance between thymus-derived and bone marrow-derived natural killer cells in the spleen.

Chronic alcohol consumption perturbs the balance between thymus-derived and bone marrow-derived natural killer cells in the spleen. Research Abstract Details 

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Chronic alcohol consumption perturbs the balance between thymus-derived and bone marrow-derived natural killer cells in the spleen. Abstract Text:

Hui Zhang,Gary G Meadows,Hui Zhang,Gary G Meadows,Hui Zhang,Gary G Meadows,

Alcohol consumption reduces peripheral NK cell numbers and compromises NK cell cytolytic activity; however, the underlying mechanism is not understood completely. It was found recently that the peripheral NK cell pool consists largely of bone marrow (BM)-derived and thymus-derived cells, which are phenotypically and functionally different. The effects of alcohol consumption on these subpopulations have not been studied previously. Using a well-established alcohol-feeding model, we found that chronic alcohol consumption decreases the percentage and number of peripheral NK cells, especially those expressing a mature phenotype. Alcohol consumption did not alter NK cells in the thymus. NK cells in the BM were increased significantly; however, proliferation rate was not altered by alcohol consumption, which increased CD127(+) and decreased Ly49D(+) NK cells in the spleen but not in the BM. Chronic alcohol consumption increased IFN-gamma-producing NK cells and GATA-3 expression in splenic NK cells. Collectively, these results indicate that chronic alcohol consumption perturbs the balance between thymus-derived and BM-derived NK cells. The increased proportion of thymus-derived NK cells in the spleen likely results from impaired NK cell release from the BM.

Chronic alcohol consumption perturbs the balance between thymus-derived and bone marrow-derived natural killer cells in the spleen. Publishing Authors By Initials

H Zhang,GG Meadows,H Zhang,GG Meadows,H Zhang,GG Meadows,

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Chronic alcohol consumption perturbs the balance between thymus-derived and bone marrow-derived natural killer cells in the spleen. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of leukocyte biology

VOLUME: 83

Page Numbers: 41-7

Journal Abbreviation: J. Leukoc. Biol.

ISSN: 0741-5400

DAY: 28

MONTH: 09

YEAR: 2007

Chronic alcohol consumption perturbs the balance between thymus-derived and bone marrow-derived natural killer cells in the spleen. Information

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LANGUAGE: eng

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AFFILIATION: Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Box 646713, 110 McCoy Office Trailer, Pullman, WA 99164-6713, USA. meadows@wsu.edu.

Country: United States

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MEDLINETA: J Leukoc Biol

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