Chronic administration of beta-adrenergic agonists can mimic the stimulative effect of cold exposure on protein synthesis in rat brown adipose tissue.

Chronic administration of beta-adrenergic agonists can mimic the stimulative effect of cold exposure on protein synthesis in rat brown adipose tissue. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Chronic administration of beta-adrenergic agonists can mimic the stimulative effect of cold exposure on protein synthesis in rat brown adipose tissue. Abstract Text:

K Tsukazaki,H Nikami,Y Shimizu,T Kawada,T Yoshida,M Saito,

When mammals are exposed to a cold environment for a long time, the capacity of nonshivering thermogenesis by brown adipose tissue (BAT) increases in association with the stimulation of synthesis of some specific proteins and tissue hyperplasia, which are totally dependent on sympathetic innervation to this tissue. To clarify the roles of the adrenergic mechanisms for the cold-induced protein synthesis and hyperplasia in BAT, in this study, the effects of chronic treatment with adrenergic agonists using an osmotic mini-pump were examined in rats. Continuous administration of noradrenaline or isoproterenol (beta-agonist) for 10 days resulted in increased synthesis of the mitochondrial uncoupling protein and an isoform of glucose transporter (GLUT4), and tissue hyperplasia, in the same way as after cold exposure of the same duration. Phenylephrine (alpha-agonist) administration did not have any significant effect. Surgical sympathetic denervation completely abolished the effects of cold exposure, whereas it did not influence those of adrenergic agonists at all. These results indicate that the stimulative effects of cold exposure on protein synthesis and hyperplasia of BAT are attributable solely to the beta-adrenergic action of noradrenaline secreted from the sympathetic nerves in this tissue.

Chronic administration of beta-adrenergic agonists can mimic the stimulative effect of cold exposure on protein synthesis in rat brown adipose tissue. Publishing Authors By Initials

K Tsukazaki,H Nikami,Y Shimizu,T Kawada,T Yoshida,M Saito,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, wistar research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, wistar research

PUBMED ID PMID:

MEDLINE DATE:

Chronic administration of beta-adrenergic agonists can mimic the stimulative effect of cold exposure on protein synthesis in rat brown adipose tissue. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 117

Page Numbers: 96-100

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jan

YEAR: 1995

Chronic administration of beta-adrenergic agonists can mimic the stimulative effect of cold exposure on protein synthesis in rat brown adipose tissue. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376600

Chronic administration of beta-adrenergic agonists can mimic the stimulative effect of cold exposure on protein synthesis in rat brown adipose tissue. Keywords Mesh Terms:

KEYWORDS: Rats, Wistar

MESH TERMS: metabolism

Chemical & Substance for Abstract: Chronic administration of beta-adrenergic agonists can mimic the stimulative effect of cold exposure on protein synthesis in rat brown adipose tissue. Information

Substance Name: Slc2a4 protein, rat

Registry Number: 0

Grant and Affiliation Information for Chronic administration of beta-adrenergic agonists can mimic the stimulative effect of cold exposure on protein synthesis in rat brown adipose tissue.

AFFILIATION: Department of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo.

Country: JAPAN

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Biochem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Chronic administration of beta-adrenergic agonists can mimic the stimulative effect of cold exposure on protein synthesis in rat brown adipose tissue Related Publications

• A case report of thrombotic thrombocytopenic purpura and severe acute renal failure post non-myeloablative allogeneic peripheral blood stem cell transplantation treated with plasma exchange and hemodialysis.
• ANP is cleared much faster than BNP in patients with congestive heart failure.
• Acute carotid arterial occlusion after burr hole surgery for chronic subdural haematoma in moyamoya disease.
• Brownian motion of helical flagella.
• Change in atrial flutter wave morphology-insight into the sources of electrocardiographic variants in common atrial flutter.
• Congenital left ventricular diverticulum in an adult.
• Effects of Methamphetamine on Cortisone Concentration, NK Cell Activity and Mitogen Response of T-lymphocytes in Female Cynomolgus Monkeys.
• Effects of Plastoquinones from the Brown Alga Sargassum micracanthum and a New Chromene Derivative Converted from the Plastoquinones on Acute Gastric Lesions in Rats.
• Effects of gangliosides on ethanol-induced neurodegeneration in the developing mouse brain.
• Electrophysiological properties of the atrium after cardioversion of chronic atrial fibrillation.
• Expression of angiotensin II type I receptor in human cirrhotic livers: Its relation to fibrosis and portal hypertension.
• Identification of novel n-4 series polyunsaturated fatty acids in a deep-sea clam, Calyptogena phaseoliformis.
• Impact of laparoscopic cystectomy on fecundity of infertility patients with ovarian endometrioma.
• Importance of chroman ring and tyrosine phosphorylation in the subtype-specific translocation and activation of diacylglycerol kinase alpha by D-alpha-tocopherol.
• Intramolecular alpha-helix-beta-structure-random coil transition in polypeptides I. Equilibrium case.
• Intramolecular alpha-helix-beta-structure-random coil transition in polypeptides II. Dynamic case.
• Laparoscopy should be strongly considered for women with unexplained infertility.
• Measurement and Analysis of Reflex Responses to Perturbation during Walking-Towards the Realization of Artificial Reflex.
• Olanzapine potentiates neuronal survival and neural stem cell differentiation: regulation of endoplasmic reticulum stress response proteins.
• Periodontal regeneration of transplanted rat teeth subcutaneously after cryopreservation.
• Phenotypic changes associated with exogenous expression of p16INK4a in human glioma cells.
• Prostate-specific antigen cut-off point of 2.5 ng/mL and increasing the number of prostate biopsies results in the detection of curable prostate cancer even in Japanese population.
• Second branchial cleft cyst with "cyst-within-cyst" appearance.
• Spatial distribution of mDLG6 mRNA in embryonic and adult mouse brain.
• Spatiotemporal Analysis of the Molecular Interaction between PICK1 and PKC.
• Sulfonamide derivatives as new potent and selective CB2 cannabinoid receptor agonists.
• The random walk description for isotope exchange in a polypeptide.
• Threshold-like pattern of neuronal activation in the hypothalamus during treadmill running: establishment of a minimum running stress (MRS) rat model.
• [Affected State due to Excessive Occlusal Force.]
• [Repair of bone tissue using rhBMP-2]