ChREBP, a transcriptional regulator of glucose and lipid metabolism.

ChREBP, a transcriptional regulator of glucose and lipid metabolism. Research Abstract Details 

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ChREBP, a transcriptional regulator of glucose and lipid metabolism. Abstract Text:

Catherine Postic,Renaud Dentin,Pierre-Damien Denechaud,Jean Girard,

Dysregulations in hepatic lipid synthesis are often associated with obesity and type 2 diabetes, and therefore a perfect understanding of the regulation of this metabolic pathway appears essential to identify potential therapeutic targets. Recently, the transcription factor ChREBP (carbohydrate-responsive element-binding protein) has emerged as a major mediator of glucose action on lipogenic gene expression and as a key determinant of lipid synthesis in vivo. Indeed, liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in obese ob/ob mice. Since ChREBP cellular localization is a determinant of its functional activity, a better knowledge of the mechanisms involved in regulating its nucleo-cytoplasmic shuttling and/or its post-translational activation is crucial in both physiology and physiopathology. Here, we review some of the studies that have begun to elucidate the regulation and function of this key transcription factor in liver.

ChREBP, a transcriptional regulator of glucose and lipid metabolism. Publishing Authors By Initials

C Postic,R Dentin,PD Denechaud,J Girard,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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ChREBP, a transcriptional regulator of glucose and lipid metabolism. Journal Published:

PUBLICATION TYPE: Review

Journal: Annual review of nutrition

VOLUME: 27

Page Numbers: 179-92

Journal Abbreviation: Annu. Rev. Nutr.

ISSN: 0199-9885

DAY: 26

MONTH: 11

YEAR: 2007

ChREBP, a transcriptional regulator of glucose and lipid metabolism. Information

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LANGUAGE: eng

NlmUniqueID: 8209988

ChREBP, a transcriptional regulator of glucose and lipid metabolism. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: ChREBP, a transcriptional regulator of glucose and lipid metabolism. Information

Substance Name: Glucose

Registry Number: 50-99-7

Grant and Affiliation Information for ChREBP, a transcriptional regulator of glucose and lipid metabolism.

AFFILIATION: Département d'Endocrinologie, Métabolisme et Cancer, Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France. postic@cochin.inserm.fr

Country: United States

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MEDLINETA: Annu Rev Nutr

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