Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health.

Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health. Abstract Text:

Paul Bentley,Jon Driver,Ray J Dolan,

Visuo-attentional deficits occur early in Alzheimer's disease (AD) and are considered more responsive to pro-cholinergic therapy than characteristic memory disturbances. We hypothesised that neural responses in AD during visuo-attentional processing would be impaired relative to controls, yet partially susceptible to improvement with the cholinesterase inhibitor physostigmine. We studied 16 mild AD patients and 17 age-matched healthy controls, using fMRI-scanning to enable within-subject placebo-controlled comparisons of effects of physostigmine on stimulus- and attention- related brain activations, plus between-group comparisons for these. Subjects viewed face or building stimuli while performing a shallow judgement (colour of image) or a deep judgement (young/old age of depicted face or building). Behaviourally, AD subjects performed slower than controls in both tasks, while physostigmine benefited the patients for the more demanding age-judgement task. Stimulus-selective (face minus building, and vice versa) BOLD signals in precuneus and posterior parahippocampal cortex were attenuated in patients relative to controls, but increased following physostigmine. By contrast, face-selective responses in fusiform cortex were not impaired in AD and showed decreases following physostigmine for both groups. Task-dependent responses in right parietal and prefrontal cortices were diminished in AD but improved following physostigmine. A similar pattern of group and treatment effects was observed in two extrastriate cortical regions that showed physostigmine-induced enhancement of stimulus-selectivity for the deep versus shallow task. Finally, for the healthy group, physostigmine decreased stimulus and task-dependent effects, partly due to an exaggeration of selectivity during the shallow relative to deep task. The differences in brain activations between groups and treatments were not attributable merely to performance (reaction time) differences. Our results demonstrate that physostigmine can improve both stimulus- and attention-dependent responses in functionally affected extrastriate and frontoparietal regions in AD, while perturbing the normal pattern of responses in many of the same regions in healthy controls.

Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health. Publishing Authors By Initials

P Bentley,J Driver,RJ Dolan,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Brain : a journal of neurology

VOLUME: 131

Page Numbers: 409-24

Journal Abbreviation: Brain

ISSN: 1460-2156

DAY: 12

MONTH: 12

YEAR: 2007

Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372537

Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health.

AFFILIATION: Wellcome Centre for Neuroimaging at UCL, London WC1N 3BG, UK. p.bentley@fil.ion.ucl.ac.uk

Country: England

AGENCY: United Kingdom Wellcome T

GRANT:

ACRONYM:

MEDLINETA: Brain

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health Related Publications

• 'That's just the cesspool where they dump all the trash': exploring working class men's perceptions and experiences of social capital and health.
• A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity.
• Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health.
• Differential ethylene sensitivity of epidermal cells is involved in the establishment of cell pattern in the Arabidopsis root.
• Distinct and convergent visual processing of high and low spatial frequency information in faces.
• Electromotile hearing: acoustic tones mask psychophysical response to high-frequency electrical stimulation of intact guinea pig cochleae.
• Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activity.
• Enhanced emotion-induced amnesia in borderline personality disorder.
• Exploring efferent-mediated DPOAE adaptation in three different guinea pig strains.
• Finding value. ACHE provides exceptional services and benefits to its members.
• Gastrointestinal staple line reinforcement.
• Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia.
• Human pavlovian instrumental transfer.
• Identification of genetic variants contributing to cisplatin-induced cytotoxicity by use of a genomewide approach.
• Increased burst pressure in gastrointestinal staple-lines using reinforcement with a bioprosthetic material.
• Instability in the diagnosis of metabolic syndrome in adolescents.
• Keynote address: revaluing the orbital prefrontal cortex.
• Mapping genes that contribute to daunorubicin-induced cytotoxicity.
• Mesenteric artery occlusion secondary to activated protein C resistance: a life-threatening combination.
• Molecular mechanisms of resistance and toxicity associated with platinating agents.
• Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS consortium trial.
• Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals.
• Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice.
• Role of features and second-order spatial relations in face discrimination, face recognition, and individual face skills: behavioral and functional magnetic resonance imaging data.
• Social regulation of affective experience of humor.
• Soul searching: a brief history of the mind/body debate in the neurosciences.
• Sowing the seeds of dialogue: public engagement through plant science.
• Tyr346-->Cys mutation results in factor VIII:C assay discrepancy and a normal bleeding phenotype - is this mild haemophilia A?
• University of Florida College of Dentistry's "Case of the Month": Evaluating a web-based continuing dental education course for clinical oral pathology.
• Vagus nerve stimulation for treatment-resistant depression: behavioral and neural effects on encoding negative material.