Cholesterol surrogates incorporating a benzophenone as part of the sterol tetracycle.

Cholesterol surrogates incorporating a benzophenone as part of the sterol tetracycle. Research Abstract Details 

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Cholesterol surrogates incorporating a benzophenone as part of the sterol tetracycle. Abstract Text:

Yonghong Gan,Thomas A Spencer,

Photoactivatable analogues 4-6 of cholesterol (1), having their cross-linking site in the ring D sterol region, have been synthesized starting from bromotetralone 14 via enantioselective Robinson annulation to enone 13 and Suzuki carbonylative coupling to the appropriate phenylboronic acid. Each of 4-6 was shown to substitute successfully for 1 in an assay of apo A-I-induced cellular cholesterol efflux, indicating that these analogues equilibrated with 1 in all major cellular pools.

Cholesterol surrogates incorporating a benzophenone as part of the sterol tetracycle. Publishing Authors By Initials

Y Gan,TA Spencer,

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Cholesterol surrogates incorporating a benzophenone as part of the sterol tetracycle. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of organic chemistry

VOLUME: 71

Page Numbers: 5870-5

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ISSN: 0022-3263

DAY: 4

MONTH: Aug

YEAR: 2006

Cholesterol surrogates incorporating a benzophenone as part of the sterol tetracycle. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Cholesterol surrogates incorporating a benzophenone as part of the sterol tetracycle.

AFFILIATION: Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, USA.

Country: United States

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MEDLINETA: J Org Chem

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