Cholesterol homeostasis in the developing brain: a possible new target for ethanol.

Cholesterol homeostasis in the developing brain: a possible new target for ethanol. Research Abstract Details 

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Cholesterol homeostasis in the developing brain: a possible new target for ethanol. Abstract Text:

M Guizzetti,L G Costa,

Cholesterol is an essential component of cell membranes and plays an important role in signal transduction. This brief overview presents evidence from the literature that ethanol may affect cholesterol homeostasis and that, in the developing brain, this may be involved in its developmental neurotoxicity. The effects caused by inborn errors of cholesterol synthesis and by in utero ethanol exposure present several similarities in humans (eg, Smith-Lemli-Opitz syndrome and fetal alcohol syndrome), as well as in animal models. Ethanol has a cholesterol-reducing effect on the cardiovascular system, and a protective effect against Alzheimer's disease, whose pathogenesis has been linked to altered cholesterol homeostasis in the brain. In vitro, ethanol affects several functions that are mediated by cholesterol and important for brain development, such as glial cell proliferation, synaptogenesis, neuronal survival and neurite outgrowth. The brain contains high levels of cholesterol, mostly synthesized in situ. Astrocytes produce large amounts of cholesterol that can be released by these cells and utilized by neurons to form synapses. Ethanol up-regulates the cholesterol transporter ATP binding cassette A1 and cholesterol efflux from primary astrocyte cultures without affecting cholesterol synthesis.

Cholesterol homeostasis in the developing brain: a possible new target for ethanol. Publishing Authors By Initials

M Guizzetti,LG Costa,

For similar animals: chordata: vertebrates: mammals: primates: haplorhini: catarrhini: hominidae: humans research abstracts see: animals: chordata: vertebrates: mammals: primates: haplorhini: catarrhini: hominidae: humans research

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Cholesterol homeostasis in the developing brain: a possible new target for ethanol. Journal Published:

PUBLICATION TYPE: Review

Journal: Human & experimental toxicology

VOLUME: 26

Page Numbers: 355-60

Journal Abbreviation:

ISSN: 0960-3271

DAY: 3

MONTH: Apr

YEAR: 2007

Cholesterol homeostasis in the developing brain: a possible new target for ethanol. Information

Number of References: 66

LANGUAGE: eng

NlmUniqueID: 9004560

Cholesterol homeostasis in the developing brain: a possible new target for ethanol. Keywords Mesh Terms:

KEYWORDS: Humans

MESH TERMS: drug effects

Chemical & Substance for Abstract: Cholesterol homeostasis in the developing brain: a possible new target for ethanol. Information

Substance Name: Ethanol

Registry Number: 64-17-5

Grant and Affiliation Information for Cholesterol homeostasis in the developing brain: a possible new target for ethanol.

AFFILIATION: Department of Environmental and Occupational Health Sciences, University of Washington, Seattle 98105, USA. marinag@u.washington.edu

Country: England

AGENCY: United States NIEHS

GRANT: P30ES07033

ACRONYM: ES

MEDLINETA: Hum Exp Toxicol

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