Cholestatic liver diseases: slow progress in understanding and treating slowly progressive disorders.

Cholestatic liver diseases: slow progress in understanding and treating slowly progressive disorders. Research Abstract Details 

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Cholestatic liver diseases: slow progress in understanding and treating slowly progressive disorders. Abstract Text:

F P Vleggaar,N A Van Ooteghem,H R Van Buuren,G P Van Berge Henegouwen,

BACKGROUND: Cholestatic liver diseases are characterized by failure of normal amounts of physiological bile to reach the gastrointestinal tract. Any interference with normal bile flow from the canalicular membrane of the hepatocyte to the distal common bile duct may result in cholestasis. METHODS: Literature review. RESULTS: In primary biliary cirrhosis (PBC), the small intrahepatic bile ducts are destructed, resulting in obstruction of intrahepatic bile flow, whereas extrahepatic and/or intrahepatic biliary strictures block the passage of bile towards the intestine in primary sclerosing cholangitis (PSC). In contrast, the biliary tree is morphologically unaffected in less common cholestatic liver diseases as benign recurrent intrahepatic cholestasis (BRIC) and progressive familiar intrahepatic cholestasis (PFIC1-4). Genetic defects in hepatic canalicular transport mechanisms and bile salt synthesis deficiencies seem to underlie these types of cholestatic disorders. CONCLUSION: Recent advances in understanding and treatment of cholestatic liver diseases may help in better diagnosing and treating the various conditions characterized by cholestasis.

Cholestatic liver diseases: slow progress in understanding and treating slowly progressive disorders. Publishing Authors By Initials

FP Vleggaar,NA Van Ooteghem,HR Van Buuren,GP Van Berge Henegouwen,

For similar diagnosis: prognosis research abstracts see: diagnosis: prognosis research

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Cholestatic liver diseases: slow progress in understanding and treating slowly progressive disorders. Journal Published:

PUBLICATION TYPE: Review

Journal: Scandinavian journal of gastroenterology. Suppleme

VOLUME:

Page Numbers: 86-92

Journal Abbreviation: Scand. J. Gastroenterol. Suppl

ISSN: 0085-5928

DAY: 13

MONTH: 02

YEAR: 2000

Cholestatic liver diseases: slow progress in understanding and treating slowly progressive disorders. Information

Number of References: 72

LANGUAGE: eng

NlmUniqueID: 437034

Cholestatic liver diseases: slow progress in understanding and treating slowly progressive disorders. Keywords Mesh Terms:

KEYWORDS: Prognosis

MESH TERMS: pathology

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Substance Name: Genetic Markers

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Grant and Affiliation Information for Cholestatic liver diseases: slow progress in understanding and treating slowly progressive disorders.

AFFILIATION: Dept. of Hepatogastroenterology, University Hospital Rotterdam, The Netherlands.

Country: Norway

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MEDLINETA: Scand J Gastroenterol Suppl

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