Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet.

Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet. Research Abstract Details 

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Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet. Abstract Text:

Matthew T Flowers,Albert K Groen,Angie Tebon Oler,Mark P Keller,Younjeong Choi,Kathryn L Schueler,Oliver C Richards,Hong Lan,Makoto Miyazaki,Folkert Kuipers,Christina M Kendziorski,James M Ntambi,Alan D Attie,

Stearoyl-coenzyme A desaturase 1-deficient (SCD1(-/-)) mice have impaired MUFA synthesis. When maintained on a very low-fat (VLF) diet, SCD1(-/-) mice developed severe hypercholesterolemia, characterized by an increase in apolipoprotein B (apoB)-containing lipoproteins and the appearance of lipoprotein X. The rate of LDL clearance was decreased in VLF SCD1(-/-) mice relative to VLF SCD1(+/+) mice, indicating that reduced apoB-containing lipoprotein clearance contributed to the hypercholesterolemia. Additionally, HDL-cholesterol was dramatically reduced in these mice. The presence of increased plasma bile acids, bilirubin, and aminotransferases in the VLF SCD1(-/-) mice is indicative of cholestasis. Supplementation of the VLF diet with MUFA- and PUFA-rich canola oil, but not saturated fat-rich hydrogenated coconut oil, prevented these plasma phenotypes. However, dietary oleate was not as effective as canola oil in reducing LDL-cholesterol, signifying a role for dietary PUFA deficiency in the development of this phenotype. These results indicate that the lack of SCD1 results in an increased requirement for dietary unsaturated fat to compensate for impaired MUFA synthesis and to prevent hypercholesterolemia and hepatic dysfunction. Therefore, endogenous MUFA synthesis is essential during dietary unsaturated fat insufficiency and influences the dietary requirement of PUFA.

Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet. Publishing Authors By Initials

MT Flowers,AK Groen,AT Oler,MP Keller,Y Choi,KL Schueler,OC Richards,H Lan,M Miyazaki,F Kuipers,CM Kendziorski,JM Ntambi,AD Attie,

For similar lipids: glycerides: triglycerides research abstracts see: lipids: glycerides: triglycerides research

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Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of lipid research

VOLUME: 47

Page Numbers: 2668-80

Journal Abbreviation: J. Lipid Res.

ISSN: 0022-2275

DAY: 27

MONTH: 09

YEAR: 2006

Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet. Information

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LANGUAGE: eng

NlmUniqueID: 376606

Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet. Keywords Mesh Terms:

KEYWORDS: Triglycerides

MESH TERMS: metabolism

Chemical & Substance for Abstract: Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet. Information

Substance Name: Stearoyl-CoA Desaturase

Registry Number: EC 1.14.99.5

Grant and Affiliation Information for Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet.

AFFILIATION: Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL-56593

ACRONYM: HL

MEDLINETA: J Lipid Res

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