Cholecystectomy and endometrial cancer: a marker of long-term elevated estrogen exposure?

Cholecystectomy and endometrial cancer: a marker of long-term elevated estrogen exposure? Research Abstract Details 

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Cholecystectomy and endometrial cancer: a marker of long-term elevated estrogen exposure? Abstract Text:

L M Morimoto,P A Newcomb,J M Hampton,A Trentham-Dietz,

Excess hormones, both endogenous and exogenous, are implicated in the etiology of endometrial cancer. We considered whether having had gallstones or a cholecystectomy (surgery to remove the gallbladder), which are more common in women who are obese and who use exogenous hormones, might be a marker for high lifetime levels of estrogen. We conducted a population-based study of endometrial cancer cases and community controls in women aged 40-79 years. Participants completed an interviewer-administered questionnaire that elicited exposures prior to diagnosis or reference date, including history of gallstones and cholecystectomy, as well as reproductive history, lifetime body mass, smoking, postmenopausal hormone (PMH) use, and other risk factors. Compared to controls, cholecystectomy was associated with a 50% increased risk of developing endometrial cancer (odds ratio = 1.5 [1.1-2.0]). The relationship appeared to depend upon PMH user status; the association was observed only among never hormone users. Body mass index did not appear to modify this relationship. Having a diagnosis of gallstones was also associated with endometrial cancer, although to a lesser magnitude. Although other etiologic factors may play a role in the relation between cholecystectomy and endometrial cancer, the current analysis suggests that this association is attributable, at least in part, to the sharing of hormonal risk factors.

Cholecystectomy and endometrial cancer: a marker of long-term elevated estrogen exposure? Publishing Authors By Initials

LM Morimoto,PA Newcomb,JM Hampton,A Trentham-Dietz,

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Cholecystectomy and endometrial cancer: a marker of long-term elevated estrogen exposure? Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: International journal of gynecological cancer : of

VOLUME: 16

Page Numbers: 1348-53

Journal Abbreviation: Int. J. Gynecol. Cancer

ISSN: 1048-891X

DAY: 3

MONTH: 12

YEAR: 2007

Cholecystectomy and endometrial cancer: a marker of long-term elevated estrogen exposure? Information

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LANGUAGE: eng

NlmUniqueID: 9111626

Cholecystectomy and endometrial cancer: a marker of long-term elevated estrogen exposure? Keywords Mesh Terms:

KEYWORDS: Time

MESH TERMS: complications

Chemical & Substance for Abstract: Cholecystectomy and endometrial cancer: a marker of long-term elevated estrogen exposure? Information

Substance Name: Estrogens

Registry Number: 0

Grant and Affiliation Information for Cholecystectomy and endometrial cancer: a marker of long-term elevated estrogen exposure?

AFFILIATION: Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., Seattle, WA 98109, USA. lmorimot@fhcrc.org

Country: United States

AGENCY: United States NCI

GRANT: CA 47147

ACRONYM: CA

MEDLINETA: Int J Gynecol Cancer

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