PURPOSE OF REVIEW: Cholangiocarcinomas are malignancies arising from biliary tract epithelia that are associated with a poor prognosis. The diagnosis, evaluation and management of these tumors continue to be clinically challenging. In this review, we will discuss recent information that may influence the approach to the diagnosis and management of this devastating tumor. RECENT FINDINGS: Epidemiological studies are defining patient groups at increased risk of cancer in regions of low prevalence. Emerging approaches that may improve evaluation and management include the potential use of genomic and proteomic markers, cytogenetic and digital image analysis, endoscopic ultrasound with fine needle aspiration, and cholangioscopy. Adoption of aggressive surgical approaches along with the use of preoperative portal vein embolization, hepatic and caudate lobe resection and preoperative laparoscopy may improve survival. SUMMARY: Recent conceptual and technical advances will impact the clinical approach to cholangiocarcinoma and offer the promise of improving outcomes from this difficult tumor.
Cholangiocarcinoma: emerging approaches to a challenging cancer. Publishing Authors By Initials
Cholangiocarcinoma: emerging approaches to a challenging cancer. Journal Published:
PUBLICATION TYPE: Review
Journal: Current opinion in gastroenterology
VOLUME: 23
Page Numbers: 317-23
Journal Abbreviation:
ISSN: 0267-1379
DAY: 3
MONTH: May
YEAR: 2007
Cholangiocarcinoma: emerging approaches to a challenging cancer. Information
Number of References:
LANGUAGE: eng
NlmUniqueID: 8506887
Cholangiocarcinoma: emerging approaches to a challenging cancer. Keywords Mesh Terms:
KEYWORDS: World Health
MESH TERMS: trends
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Grant and Affiliation Information for Cholangiocarcinoma: emerging approaches to a challenging cancer.
AFFILIATION: Department of Internal Medicine,Scott and White Clinic, Texas A&M University Health Science Center, Temple, TX 76508, USA. tpatel@swmail.sw.org
Country: United States
AGENCY: United States NIDDK
GRANT: DK069370
ACRONYM: DK
MEDLINETA: Curr Opin Gastroenterol
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