Chlamydophilal antigens induce foam cell formation via c-Jun NH2-terminal kinase.

Chlamydophilal antigens induce foam cell formation via c-Jun NH2-terminal kinase. Research Abstract Details 

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Chlamydophilal antigens induce foam cell formation via c-Jun NH2-terminal kinase. Abstract Text:

Takatoshi Kitazawa,Atsuhito Fukushima,Shu Okugawa,Shintaro Yanagimoto,Kunihisa Tsukada,Keita Tatsuno,Kazuhiko Koike,Satoshi Kimura,Toshio Kishimoto,Yoshikazu Shibasaki,Yasuo Ota,Takatoshi Kitazawa,Atsuhito Fukushima,Shu Okugawa,Shintaro Yanagimoto,Kunihisa Tsukada,Keita Tatsuno,Kazuhiko Koike,Satoshi Kimura,Toshio Kishimoto,Yoshikazu Shibasaki,Yasuo Ota,Takatoshi Kitazawa,Atsuhito Fukushima,Shu Okugawa,Shintaro Yanagimoto,Kunihisa Tsukada,Keita Tatsuno,Kazuhiko Koike,Satoshi Kimura,Toshio Kishimoto,Yoshikazu Shibasaki,Yasuo Ota,

Chlamydophila pneumoniae is known to be associated with atherosclerosis. Recent studies have reported that components of Chlamydophila pneumoniae (chlamydophilal antigens) induce foam cell formation in macrophages. However, the mechanism of foam cell formation induced by chlamydophilal antigens has yet to be elucidated. In this paper, we first found that mitogen-activated protein kinases including extracellular signal-regulated kinase, p38 and c-Jun NH2 terminal kinase are phosphorylated after stimulation by chlamydophilal antigens. We then showed that chlamydophilal antigens induce foam cell formation mainly via c-Jun NH2 terminal kinase. Finally, we demonstrated that foam cell formation and phosphorylation of mitogen-activated protein kinases induced by chlamydophilal antigens are mainly recognized through Toll-like receptor 2. These results collectively indicated that chlamydophilal antigens induce foam cell formation mainly via Toll-like receptor 2 and c-Jun NH2 terminal kinase.

Chlamydophilal antigens induce foam cell formation via c-Jun NH2-terminal kinase. Publishing Authors By Initials

T Kitazawa,A Fukushima,S Okugawa,S Yanagimoto,K Tsukada,K Tatsuno,K Koike,S Kimura,T Kishimoto,Y Shibasaki,Y Ota,T Kitazawa,A Fukushima,S Okugawa,S Yanagimoto,K Tsukada,K Tatsuno,K Koike,S Kimura,T Kishimoto,Y Shibasaki,Y Ota,T Kitazawa,A Fukushima,S Okugawa,S Yanagimoto,K Tsukada,K Tatsuno,K Koike,S Kimura,T Kishimoto,Y Shibasaki,Y Ota,

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Chlamydophilal antigens induce foam cell formation via c-Jun NH2-terminal kinase. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Microbes and infection / Institut Pasteur

VOLUME: 9

Page Numbers: 1410-4

Journal Abbreviation: Microbes Infect.

ISSN: 1286-4579

DAY: 15

MONTH: 07

YEAR: 2007

Chlamydophilal antigens induce foam cell formation via c-Jun NH2-terminal kinase. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Chlamydophilal antigens induce foam cell formation via c-Jun NH2-terminal kinase.

AFFILIATION: Department of Infectious Diseases, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

Country: France

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MEDLINETA: Microbes Infect

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