Chlamydia trachomatis species-specific induction of ezrin tyrosine phosphorylation functions in pathogen entry.

Chlamydia trachomatis species-specific induction of ezrin tyrosine phosphorylation functions in pathogen entry. Research Abstract Details 

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Chlamydia trachomatis species-specific induction of ezrin tyrosine phosphorylation functions in pathogen entry. Abstract Text:

Kena A Swanson,Deborah D Crane,Harlan D Caldwell,Kena A Swanson,Deborah D Crane,Harlan D Caldwell,

Chlamydia trachomatis is an obligate intracellular pathogen of humans that exhibits species-specific biological characteristics in its early interactions with host cells that are likely important to pathogenesis. One such characteristic is the tyrosine phosphorylation (Tyr-P) of an approximately 70-kDa polypeptide that occurs only after infection of mammalian cells by human strains. We sought to identify this protein because of its potential significance to the pathogenesis of human chlamydial infections. Using an immunoproteomic approach we identified the host protein ezrin, a member of the ezrin-radixin-moesin (ERM) protein family that serves as a physical link between host cell receptors and the actin cytoskeleton. Confocal microscopy studies showed colocalization of ezrin and actin at the tips and crypts of microvilli, the site of chlamydial attachment and entry, respectively. To demonstrate a functional role for ezrin we infected cells with a dominant-negative (DN) ezrin phenotype or treated cells with ezrin-specific small interfering RNA (siRNA). We found that both DN and siRNA-treated cells were significantly less susceptible to infection by human chlamydial strains. Moreover, we demonstrated that inhibition of infection in ezrin DN cells occurred at the stage of chlamydial entry. We hypothesize that the C. trachomatis-specific Tyr-P of ezrin might relate to an undefined species-specific mechanism of pathogen entry that involves chlamydial specific ligand(s) and host cell coreceptor usage.

Chlamydia trachomatis species-specific induction of ezrin tyrosine phosphorylation functions in pathogen entry. Publishing Authors By Initials

KA Swanson,DD Crane,HD Caldwell,KA Swanson,DD Crane,HD Caldwell,

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Chlamydia trachomatis species-specific induction of ezrin tyrosine phosphorylation functions in pathogen entry. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: Infection and immunity

VOLUME: 75

Page Numbers: 5669-77

Journal Abbreviation: Infect. Immun.

ISSN: 1098-5522

DAY: 1

MONTH: 10

YEAR: 2007

Chlamydia trachomatis species-specific induction of ezrin tyrosine phosphorylation functions in pathogen entry. Information

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LANGUAGE: eng

NlmUniqueID: 246127

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Grant and Affiliation Information for Chlamydia trachomatis species-specific induction of ezrin tyrosine phosphorylation functions in pathogen entry.

AFFILIATION: Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S. 4th St., Hamilton, MT 59840, USA.

Country: United States

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MEDLINETA: Infect Immun

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