Chiral translation and cooperative self-assembly of discrete helical structures using molecular recognition dyads.

Chiral translation and cooperative self-assembly of discrete helical structures using molecular recognition dyads. Research Abstract Details 

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Chiral translation and cooperative self-assembly of discrete helical structures using molecular recognition dyads. Abstract Text:

Hiroshi Nakade,Brian J Jordan,Hao Xu,Gang Han,Sudhanshu Srivastava,Rochelle R Arvizo,Graeme Cooke,Vincent M Rotello,

Complementary diaminopyridine (DAP) and flavin derivatives self-assemble into discrete helically stacked tetrads in hydrocarbon solvents. The self-assembled structure was demonstrated through induced circular dichroism using DAPs with chiral side-chains and flavin with achiral side-chains. Flavin derivatives with chiral side-chains were synthesized; cooperativity in the self-assembly was established through circular dichroism (CD) profiles and melting curves. It was found that placing stereocenters in both recognition units resulted in a strong bisignated profile and enhancement of complex stability, indicative of cooperative self-assembly.

Chiral translation and cooperative self-assembly of discrete helical structures using molecular recognition dyads. Publishing Authors By Initials

H Nakade,BJ Jordan,H Xu,G Han,S Srivastava,RR Arvizo,G Cooke,VM Rotello,

For similar natural sciences: chemistry: chemistry, organic: isomerism: stereoisomerism research abstracts see: natural sciences: chemistry: chemistry, organic: isomerism: stereoisomerism research

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Chiral translation and cooperative self-assembly of discrete helical structures using molecular recognition dyads. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 128

Page Numbers: 14924-9

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 22

MONTH: Nov

YEAR: 2006

Chiral translation and cooperative self-assembly of discrete helical structures using molecular recognition dyads. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Chiral translation and cooperative self-assembly of discrete helical structures using molecular recognition dyads. Keywords Mesh Terms:

KEYWORDS: Stereoisomerism

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Grant and Affiliation Information for Chiral translation and cooperative self-assembly of discrete helical structures using molecular recognition dyads.

AFFILIATION: Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: T32 GM 008515

ACRONYM: GM

MEDLINETA: J Am Chem Soc

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