Chimpanzee CD4(+) T cells are relatively insensitive to HIV-1 envelope-mediated inhibition of CD154 up-regulation.

Chimpanzee CD4(+) T cells are relatively insensitive to HIV-1 envelope-mediated inhibition of CD154 up-regulation. Research Abstract Details 

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Chimpanzee CD4(+) T cells are relatively insensitive to HIV-1 envelope-mediated inhibition of CD154 up-regulation. Abstract Text:

CD40-CD154 interaction forms a key event in regulation of crosstalk between dendritic cells and CD4 T cells. In human immunodeficiency virus (HIV)-1 infected patients CD154 expression is impaired, and the resulting loss of immune responsiveness by CD4(+) T cells contributes to a progressive state of immunodeficiency in humans. Although chimpanzees are susceptible to chronic HIV-1/SIVcpz infection, they are relatively resistant to the onset of AIDS. This relative resistance is characterized by maintenance of CD4(+) T cell populations and function, which is highly compromised in human patients. In our cohort of chronically HIV-1- and SIVcpz-infected chimpanzees, we demonstrated the capacity to produce IL-2, following CD3/CD28 stimulation, as well as preserved CD154 up-regulation. Cross-linking of CD4 with mAb was found to inhibit CD3/CD28-induced up-regulation of CD154 equally in chimpanzees and humans. However, specific cross-linking with trimeric recombinant HIV-1 gp140 revealed reduced sensitivity for inhibition of CD154 up-regulation in chimpanzees, requiring fourfold higher concentrations of viral protein. Chimpanzee CD4(+) T cells are thus less sensitive to the immune-suppressive effect of low-dose HIV-1 envelope protein than human CD4(+) T cells.

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Chimpanzee CD4(+) T cells are relatively insensitive to HIV-1 envelope-mediated inhibition of CD154 up-regulation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of immunology

VOLUME: 38

Page Numbers: 1164-72

Journal Abbreviation: Eur. J. Immunol.

ISSN: 0014-2980

DAY: 16

MONTH: Apr

YEAR: 2008

Chimpanzee CD4(+) T cells are relatively insensitive to HIV-1 envelope-mediated inhibition of CD154 up-regulation. Information

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LANGUAGE: eng

NlmUniqueID: 1273201

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Grant and Affiliation Information for Chimpanzee CD4(+) T cells are relatively insensitive to HIV-1 envelope-mediated inhibition of CD154 up-regulation.

AFFILIATION: Biomedical Primate Research Centre, Department of Virology, Rijswijk, The Netherlands.

Country: Germany

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MEDLINETA: Eur J Immunol

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