Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma.

Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma. Research Abstract Details 

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Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma. Abstract Text:

Fritz C Eilber,Murray F Brennan,Frederick R Eilber,Jeffery J Eckardt,Stephen R Grobmyer,Elyn Riedel,Charles Forscher,Robert G Maki,Samuel Singer,

PURPOSE: To determine if ifosfamide-based chemotherapy (IF) offers a survival benefit to adult patients with primary extremity synovial sarcoma. PATIENTS AND METHODS: Prospectively collected patient data from 2 institutions was used to identify all adult patients (>or=16 years) with >or=5 cm, deep, primary, extremity, synovial sarcoma that underwent surgical treatment of cure from 1990 to 2002. A total of 101 patients were identified and the median follow-up for survivors was 58 months. Clinical, pathologic, and treatment variables were analyzed for disease-specific survival (DSS), distant recurrence-free survival (DRFS), and local recurrence-free survival (LRFS). RESULTS: Sixty-eight (67%) patients were treated with IF and 33 (33%) patients received no chemotherapy (NoC) for the primary tumor. The characteristics of the IF-treated patients [median tumor size = 7.2 cm; monophasic n = 46 (68%)] were similar to NoC patients [median tumor size = 7 cm; monophasic n = 23 (70%)]. The 4-year DSS of the IF-treated patients was 88% compared with 67% for the NoC patients (P = 0.01). Smaller size (HR = 0.3 per 5-cm decrease, P < 0.0001) and treatment with IF (HR = 0.3 compared with NoC, P = 0.007) were independently associated with an improved DSS. Treatment with IF was independently associated with an improved DRFS (HR = 0.4, P = 0.03) but not associated with an improved LRFS (P = 0.39). CONCLUSION: Ifosfamide-based chemotherapy was associated with an improved DSS in adult patients with high-risk, primary, extremity, synovial sarcoma and should be considered in the treatment of such patients.

Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma. Publishing Authors By Initials

FC Eilber,MF Brennan,FR Eilber,JJ Eckardt,SR Grobmyer,E Riedel,C Forscher,RG Maki,S Singer,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Annals of surgery

VOLUME: 246

Page Numbers: 105-13

Journal Abbreviation: Ann. Surg.

ISSN: 0003-4932

DAY: 3

MONTH: Jul

YEAR: 2007

Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372354

Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: trends

Chemical & Substance for Abstract: Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma. Information

Substance Name: Ifosfamide

Registry Number: 3778-73-2

Grant and Affiliation Information for Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma.

AFFILIATION: Division of Surgical Oncology, University of California Los Angeles, Los Angeles, CA, USA.

Country: United States

AGENCY: United States NCI

GRANT: P01CA47179

ACRONYM: CA

MEDLINETA: Ann Surg

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