[Chemotherapy guidance of the drug sensitivity test in vitro in human laryngeal squamous cell carcinoma]

[Chemotherapy guidance of the drug sensitivity test in vitro in human laryngeal squamous cell carcinoma] Research Abstract Details 

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[Chemotherapy guidance of the drug sensitivity test in vitro in human laryngeal squamous cell carcinoma] Abstract Text:

Sulin Zhang,Weijia Kong,

OBJECTIVE: Consequently, strong emphasis has been placed on finding appropriate approach to achieve optimal treatment outcome. This study analyzed the drug sensitivity of Hep-2 cells at concentration-dependent and time-dependent in vitro. METHOD: Nonradioactive cell counting Kit-8 (Dojindo, Kumamoto, Japan) was used to asses growth inhibition of cancer cells by 5-FU, Carboplatin and pacilitaxel (TXL) against each concentration and exposure time. We selected optimal dose and administration regimen through comparing all the cure effect. RESULT: The drug sensitivity test data revealed that 5-FU inhibited cell growth dependently on concentration and time, that TXL did dependently on time, and that Carboplatin did dependently on concentration. CONCLUSION: Dose and administration methods both affect the treatment outcomes. So the drug sensitivity test in vitro dose provide clinical therapy with the optimal dose and administration regimen.

[Chemotherapy guidance of the drug sensitivity test in vitro in human laryngeal squamous cell carcinoma] Publishing Authors By Initials

S Zhang,W Kong,

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[Chemotherapy guidance of the drug sensitivity test in vitro in human laryngeal squamous cell carcinoma] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Lin chuang er bi yan hou ke za zhi = Journal of cl

VOLUME: 20

Page Numbers: 711-3

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ISSN: 1001-1781

DAY: 12

MONTH: Aug

YEAR: 2006

[Chemotherapy guidance of the drug sensitivity test in vitro in human laryngeal squamous cell carcinoma] Information

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LANGUAGE: chi

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AFFILIATION: Department of Otolaryngology, Union Hospital, Huazhong University of Science and Technology, Wuhan, 430022, China.

Country: China

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MEDLINETA: Lin Chuang Er Bi Yan Hou Ke Za

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