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Chemoprevention of Prostate Cancer through Dietary Agents: Progress and Promise.

Chemoprevention of Prostate Cancer through Dietary Agents: Progress and Promise. Research Abstract Details 

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  • Chemoprevention of Prostate Cancer through Dietary Agents: Progress and Promise. Abstract Text:

    deeba n syedDeeba N Syed,naghma khanNaghma Khan,farrukh afaqFarrukh Afaq,hasan mukhtarHasan Mukhtar,deeba n syedDeeba N Syed,naghma khanNaghma Khan,farrukh afaqFarrukh Afaq,hasan mukhtarHasan Mukhtar,

    Prostate cancer (CaP) is second only to lung cancer as the cause of cancer-related deaths in American men and is responsible for over 29,000 deaths per year. One promising approach to reduce the incidence of CaP is through chemoprevention, which has been recognized as a plausible and cost-effective approach to reduce cancer morbidity and mortality by inhibiting precancerous events before the occurrence of clinical disease. Indeed, CaP is an ideal candidate disease for chemoprevention because it is typically diagnosed in the elderly population with a relatively slower rate of growth and progression, and therefore, even a modest delay in the development of cancer, achieved through pharmacologic or nutritional intervention, could result in substantial reduction in the incidence of clinically detectable disease. In this review, we have summarized the recent investigations and mechanistic studies on CaP chemoprevention using dietary agents, such as selenium, vitamins D and E, lycopene, phytoestrogens, flavonoids, and green tea polyphenols. Well-designed trials are required to delineate the potential clinical usefulness of these agents through issues, such as determining the optimal period and route of administration, systemic bioavailability, optimal dosing and toxicity of the agent, and single or combinatorial approach. It is hoped that, combining the knowledge based on agents with targets, effective approaches for CaP chemoprevention can be established. (Cancer Epidemiol Biomarkers Prev 2007;16(11):2193-204).

    Chemoprevention of Prostate Cancer through Dietary Agents: Progress and Promise. Publishing Authors By Initials

    dn syedDN Syed,n khanN Khan,f afaqF Afaq,h mukhtarH Mukhtar,dn syedDN Syed,n khanN Khan,f afaqF Afaq,h mukhtarH Mukhtar,

    For similar abstracts research abstracts see: abstracts research

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    Chemoprevention of Prostate Cancer through Dietary Agents: Progress and Promise. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Cancer epidemiology, biomarkers & prevention : a p

    VOLUME: 16

    Page Numbers: 2193-203

    Journal Abbreviation: Cancer Epidemiol. Biomarkers P

    ISSN: 1055-9965

    DAY: 16

    MONTH: Nov

    YEAR: 2007

    Chemoprevention of Prostate Cancer through Dietary Agents: Progress and Promise. Information

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    LANGUAGE: eng

    NlmUniqueID: 9200608

    Chemoprevention of Prostate Cancer through Dietary Agents: Progress and Promise. Keywords Mesh Terms:

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    AFFILIATION: Department of Dermatology, University of Wisconsin, Medical Sciences Center, Room B25, 1300 University Avenue, Madison, WI 53706. hmukhtar@wisc.edu.

    Country: United States

    United States Research PublicationUnited States Research Publication

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    MEDLINETA: Cancer Epidemiol Biomarkers Pr

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