Chemical synthesis and properties of stereoregulated phosphorothioate RNAs.

Chemical synthesis and properties of stereoregulated phosphorothioate RNAs. Research Abstract Details 

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Chemical synthesis and properties of stereoregulated phosphorothioate RNAs. Abstract Text:

Takeshi Wada,Tomoaki Kondo,Satoshi Fujiwara,Terutoshi Sato,Natsuhisa Oka,

Stereoregulated oligoribonucleoside phosphorothioates were synthesized by the use of 2'-O-TBDMS-protected ribonucleoside 3'-O-oxazaphospholidine derivatives as monomers and N-(cyanomethyl)ammonium salts as activators. Diastereoselectivity of the condensation reaction was found to be highly dependent on the substituent groups of the oxazaphospholidine ring as well as the structure of the activators. By the use of the optimized oxazaphospholidine monomers and activators, stereoregulated oligoribonucleoside phosphorothioates containing four kinds of nucleobases were synthesized in good yields. Hybridization properties of thus obtained oligomers with the complementary RNAs were evaluated by the UV melting experiments.

Chemical synthesis and properties of stereoregulated phosphorothioate RNAs. Publishing Authors By Initials

T Wada,T Kondo,S Fujiwara,T Sato,N Oka,

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Chemical synthesis and properties of stereoregulated phosphorothioate RNAs. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nucleic acids symposium series (2004)

VOLUME:

Page Numbers: 119-20

Journal Abbreviation: Nucleic Acids Symp Ser (Oxf)

ISSN: 1746-8272

DAY: 21

MONTH: 11

YEAR: 2007

Chemical synthesis and properties of stereoregulated phosphorothioate RNAs. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Chemical synthesis and properties of stereoregulated phosphorothioate RNAs.

AFFILIATION: Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan. wada@k.u-tokyo.ac.jp

Country: England

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MEDLINETA: Nucleic Acids Symp Ser (Oxf)

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